Number №3, 2019 - page 40-48

Comparative evaluation of the development and occurence of the inflammatory process in prostate under its transusretral infection using the low counts of causative and debatable microorganism strains DOI: 10.29188/2222-8543-2019-11-3-40-48

Kogan M.I., Naboka Yu.L., Todorov S.S., Ismailov R.S.
Information about authors:

Kogan M.I. – Honored Scientist of the Russian Federation, Dr.Sc., Full Professor; Head, Department of Urology and Human Reproductive Health with the Course of Pediatric Urology-andrology of the Advanced Training and Specialist Professional Retraining Faculty, Rostov State Medical University (FGBOU VPO RostGMU of Russian Federation Ministry Of Healthcare); dept_kogan@mail.ru; ORCID 0000-0003-2725-3748

Naboka Y.L. – Dr.Sc., Full Professor; Head, Department of Microbiology and Virology № 1, Rostov State Medical University (FGBOU VPO RostGMU of Russian Federation Ministry Of Healthcare); nagu22@mail.ru; ORCID 0000-0002-4808-7024

Todorov S.S. – Dr.Sc., Head, Morphology Division, Rostov State Medical University Clinic (FGBOU VPO RostGMU of Russian Federation Ministry Of Healthcare); sertodorov@gmail.com; ORCID 0000-0002-8168-447X Исмаилов Р.С. – очный аспирант

Ismailov R.S. – Full-time Postgraduate student at the Department of Urology and Human Reproductive Health with the Course of Pediatric Urology-andrology of the Advanced Training and Specialist Professional Retraining Faculty, Rostov State Medical University (FGBOU VPO RostGMU of Russian Federation Ministry Of Healthcare); dr.ruslan.ismailov@gmail.com; ORCID 0000-0003-1958-9858

278

Contacts: Ismailov Ruslan Samedovich, dr.ruslan.ismailov@gmail.com

Objective. The etiological identity of debated microorganisms to the development of bacterial prostatitis is discussed. It is also not reliably determined whether low titers` causative and debated strains of microorganisms are capable of causing the development of a relevant pathological process in the prostate. The purpose of the study was to compare the bacteriological and morphological features of the development and progression of the pathological process in the prostate during its transurethral infection. Сausative and debatable strains of microorganisms in low titers were used in experimental modeling of bacterial prostatitis.

Materials and methods. Laboratory animals: 16 mature rabbits breed «New Zealand». Investigated taxa: E. coli, S. haemolyticus, Peptococcus niger; titer count – 103 CFU/ml. The biopsy specimens of the prostatic complex were evaluated bacteriologically (on an extended set of nutrient media) and pathologically (the Hematoxylin-eosin stain and light microscopy of the preparations). Processing of the research results was carried out using the soware package Statistica 10.2 (StatSoft Inc., USA).

Results and discussion. A significant bacterial contamination of the tissues of the prostatic complex in laboratory animals in a titer of 101-107 CFU/ml was achieved. When comparing the pathological evaluation of biopsy specimens with the results of bacteriological research, the presence of parallelism between the degree of dissemination and the explicitness of the relevant inflammatory changes in all biopsy specimens of the prostatic complex both during infection with causative and debated strains of microorganisms was established.

Conclusion.Thus, the data obtained demonstrate a comparable pathogenic potential of bacteria from different clusters of microorganisms. These facts mediate the need to revise the etiological aspects of the bacterial prostatitis’ development and the intensification of research in this direction.

For citation: Kogan M.I., Naboka Y.L., Todorov S.S., Ismailov R.S. Comparative evaluation of the development and occurence of the inflammatory process in prostate under its transusretral infection using the low counts of causative and debatable microorganism strains. Experimental and clinical urology 2019; (3):40-48

AttachmentSize
Download1.44 MB
bacterial prostatitis, uropathogens, experimental models, low counts

Readera - Социальная платформа публикаций

Crossref makes research outputs easy to find, cite, link, and assess