Effect of tigecycline on the production of the cytokines in peripheral blood cells in patients CRF and chronic pyelonephritis

E.N. Kareva, S.K. Jarovoiy, N.G. Moskaleva, N.S. Aleksandrov, D.A. Tihonov

In this article we present the results of the study, aimed to estimate the influence of the glycylcycline antibiotic tigecycline on the production of cytokines by mononuclear cells of the peripheral blood in 43 patients: 21 patients with chronic obstructive pyelonephritis and chronic kidney disease, both as a consequence of urolithiasis (main group), and 22 healthy men with normal kidney function without any other diseases (control group).

As the criteria of the cytokine production tumor necrosis factor alpha (TNF-alpha) and Interleukin-8 (IL-8) were chosen, being correspondingly the cytokines of pro- and counter-inflammatory action. The stimulatory influence of tigecycline was shown for TNF-alpha in patients with chronic kidney disease due to urolithiasis, while this effect was not present in patients with normal kidney function. The influence of tigecycline on IL-8 was not shown for both groups.

During the analysis of the obtained data the suggestion was made, that stimulatory effects of tigecycline on TNF-alpha production by mononuclear cells of the peripheral blood could have positive clinical effects in patients with chronic kidney disease and chronic pyelonephritis due to urolithiasis, given that the pro-inflammatory cytokines are initially lack in these patients.

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