Effect of α-Tocopherol acetate and hyperbaric oxygenation on the adaptive capacity of the cortico-sympathetic-adrenal system in partial nephrectomy

Shormanov I.S., Dryazhenkov I.G., Los' M.S., Vorchalov M.M., Komlev D.L.

Carrying out through a patient organ-saving efficient interference on a kidney is a stressful situation, causes hormone-mediator disbalance with a predominance of vasoconstrictive mechanisms in an organism. Such reaction exacerbates hypoxia of nephritic tissue, which appeared as a result of operation trauma. The most examined stress markers are adrenalin, noradrenaline and dopamine; the marker of albuminous synthesis is 11-oxycorticoid. These biologically active substances take a big physiological role in inflammation, microcirculation, pain mechanisms, autoimmune reactions and reparative processes realization of functioning tissue. The aim of investigation become the nature and catecholamine exchange and blood 11-oxycorticoid exchange of resected kidney change significance specification in different periods aer organ-saving operation, and the possibility and efficiency of their correction by using therapeutic actions which are hyperbaric oxygenation and alpha-tocopherol acetate introduction of the laboratory animals experiment , modeling a corresponding situation (kidney resection).The investigation showed that as a result of these types of treatment complex application the level acceleration stabilization of studying hormones happens. This is the evidence of introduced way of treatment positive influence on capillary bed vessels tone, ischemic tissue injury nidus size and reparation processes flow. This positive dynamic requires after-resection kidney functional ability improvement and thinner scar forming.

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