Number №2, 2020 - page 58-67

Elecrochemical lysis in the therapy of prostate cancer (experimental study) DOI: 10.29188/2222-8543-2020-12-2-58-66

For citation: Anikanova E.V., Kolontarev K.B., Guens G.P., Prilepskaya E.A., Kovylina M.V., Pushkar D.Yu. Elecrochemical lysis in the therapy of prostate cancer (experimental study). Experimental and clinical urology 2020;(2):58-66
Anikanova E.V., Kolontarev K.B., Gens G.P., Prilepskaya E.A., Kovylina M.V., Pushkar' D.Yu.
Information about authors:
  • Anikanova E.V. – doctor, Department of Oncology (urology), Central clinical hospital «Russian Railways-Medicine»; ORCID 0000-0001-8524-129X
  • Kolontarev K.B. – Dr. Sc., Professor, Department of Urology, Moscow State Medical and Dental University named after A.I. Evdokimova of the Ministry of Health of the Russian Federation,ORCID 0000-0003-4511-5998
  • Guens G.P. – Dr. Sc., Professor, Head of the Department of Oncology and Radiation Therapy, Moscow State Medical and Dental University named after A.I. Evdokimova of the Ministry of Health of the Russian Federation, ORCID 0000-0001-8708-2712
  • Prilepskaya E.A. – Research Officer of the laboratory uromorpology of the Department of Urology, Moscow State Medical and Dental University named after A.I. Evdokimova of the Ministry of Health of the Russian Federation, ORCID 0000-0001-6218-7104
  • Kovylina M.V. – PhD, Head of the laboratory uromorpology of the Department of Urology, Moscow State Medical and Dental University named after A.I. Evdokimova of the Ministry of Health of the Russian Federation, ORCID 0000-0002-2422-5058
  • Pushkar D.Yu. – Academician of the Russian Academy of Sciences, Dr. Sc., Professor, Head of the Department of Urology, Moscow State Medical and Dental University named after A.I. Evdokimova of the Ministry of Health of the Russian Federation, ORCID 0000-0002-6096-5723
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Introduction. Minimally invasive treatment of prostate cancer includes the method of electrochemical lysis, which causes damage to cells as a result of redox reactions caused by exposure to a low-energy direct current. The study objective is to evaluate the histopathological outcomes in cancer tissue and prostate tissue after electrochemical lysis.

Materials and methods. Its efficacy for prostate cancer was assessed in removed prostate glands of men with prostate cancer (n=12) by applying 2 plate electrodes to deliver current with a power of 50-70 mA and a voltage of 10 V for 180 min.

Results. Changes at electrode-tumor junctions were immediate, with dryness at the anode and oedema at the cathode. The electrochemical ablation zones were characterized as areas coagulation necrosis at the anode, colliquation necrosis at the cathode. The ablation zone was well demarcated, showing trenchant delineations between viable and nonviable tissue. The size of areas necrosis corresponded to the area of the electrodes. The depth of tissue damage was 1.7 ± 0.8 mm (0.9 to 2.5 mm) at the cathode and 4.8 ± 1.7 mm (2.1 to 7.6 mm) at the anode. Microscopically, coagulation necrosis of tissues was detected at the anode and colliquation necrosis was detected at the cathode . The electrochemical ablation zones occurred in both tumor tissue and prostate tissue.

Conclusions. Histopathological assessment of the prostate after electrochemical lysis Showed necrotic tissue in the ablation zone. No viable tissue was observed in the electrochemical lysis ablation zone. The results obtained are preliminary and need to be further evaluated in clinical trials.

Conflict of interest. The authors declare no conflict of interest.

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prostate cancer, minimally invasive treatment, electrochemical lysis, tumor destruction

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