Endocrine-mediated effect of sodium hypochlorite on functional parameters of kidneys and lithogenic properties of urine

Ivaschenko V.V., Kirpatovskiy V.I., Kalabekov A.A., Kazachenko A.V., Grebenkin M.V., Golovanov S.A., Drozhzheva V.V.

Objective. Experimental study of the effect of sodium hypochlorite (SH) on renal function and hormonal status intact rats, influencing the composition of the final urine.

Materials and methods. The study was performed on 35 white mongrel rats weighing 249-450 grams. The group of intact animals included 5 rats, they are not subjected to any stress. The control group consisted of 15 rats. They for 4 days intraperitoneally received 1.5 ml of 0.9% sodium chloride solution. Experimental group consisted of 15 rats. In that group for 4 days intraperitoneall injections with 1.5 ml of 0.06% (2.2-2.5 mg / kg / day) SH solution were made. The dynamics of functional parameters of the kidneys and the level of hormones in the blood: adrenocorticotropic hormone (ACTH), parathyroid hormone (PTH), cortisol, aldosterone have been investigated.

Results. Cortisol and PTH have a direct and systemic metabolic effects on the qualitative composition of the final urine.

Conclusions. Parenteral administration of sodium hypochlorite has a positive effect on the hormonal status of the body's endocrine system in terms of reducing the risk of developing kidney stones.

Authors declare lack of the possible conflicts of interest

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sodium hypochlorite, urolithiasis, cortisol, parathyroid hormone