Endothelial function in patients with chronic bacterial prostatitis

Shormanov I.S., Ryzhkov A.I., Solov'ev A.S.

Materials and methods: 120 patients with chronic bacterial prostatitis under clinical and laboratory exacerbation (study group) and 30 clinically healthy men (control group) were examined. The mean age in the study group was 39.6 ± 0.96 years, in the control group 36.8 ± 0.95 years. In all patients, the endothelial function markers were determined: metabolites of NO, endothelin I, free L-arginine, homocysteine, a test with reactive hyperemia was performed.

Results: The results of the measurements showed a decrease in the plasma level of total metabolites of nitric oxide in patients with exacerbation of chronic bacterial prostatitis by 18,7% to the parameters of the control group (32.1 ± 3.59 ^mol / L) (26.1 ± 2.62 ^mol / l) (р<0,05). The level of endothelin I in the blood plasma of the patients in the study group was 26,2% higher than in the control group (1.03 ± 0.37 and 1.3 ± 0.52 fmol / ml, respectively) (p <0,05). The average indices of endothelium-dependent vasodilatation in the CKD group were 55,2% worse than those of healthy men. A study of the plasma level of free L-arginine showed no significant difference in mean between healthy men in the control group and patients with exacerbation of chronic prostatitis. A study of homocysteine levels in blood revealed an increase in homocysteine content in patients with chronic bacterial prostatitis (16.03 ± 7.94 ^mol / L) by 55,3% compared to healthy men (10.32 ± 4.62 ^mol / L) (p <0,05). When performing the correlation analysis, a positive dependence of the severity of endothelial dysfunction on the duration of the disease and serum homocysteine level was revealed.

Conclusions: In patients with chronic bacterial prostatitis, there are significant violations of the systemic endothelial function. The severity of endothelial damage is directly proportional to the duration of the disease and directly depends on the level of homocysteine blood. One of the potential causes of endothelial dysfunction may be a deficiency of L-arginine.

Authors declare lack of the possible conflicts of interests.

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endothelial dysfunction, chronic bacterial prostatitis, L-arginine, homocysteine, nitrogen monooxide