Number №2, 2019 - page 140-145

Gene polymorphisms of the renin-angiotensine system in children with malformations of urinary system DOI: 10.29188/2222-8543-2019-11-2-140-145

Ahmetshin R.Z., Nurgalieva A.H., Mironov P.I.
Information about authors:
  • Akhmetshin R.Z. – PhD, chief of the Department of Pediatrics IDPO of the Bashkir state medical University, rz47@rambler.ru
  • Nurgaliyeva A.Kh. – PhD, associate Professor of genetics and fundamental medicine Bashkir state University, alfiyakh83@gmail.com,
  • Mironov P.I. – Dr. Sc., Professor of the Department of of Anesthesiology and Intensive Care Bashkir state medical University, mironovpi@mail.ru
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Purpose. The prospects of studying the genetic factors of identification of patients at high risk of malignant course of chronic kidney disease (CKD) in children is obvious. The aim of our study was a comparative assessment of the genetic predisposition to malignant CKD in children with congenital urinary tract abnormalities (VAMP) and nephritis based on the study of gene polymorphism of the reninangiotensin system.

Methods. The study included 95 children. Depending on the cause of CKD, patients were divided into two groups – comparison group (n=52), children with glomerulonephritis. Main group (n=43) patients whose development of CKD was associated with VAMP. A definition of the frequencies of alleles and genotypes of polymorphic loci of renin-angiotenzinovyh system (angiotensin receptor 1 (AGTR1, rs5186 (1166A/C)), angiotensin-converting enzyme (ACE, (Ins-Del)), angiotensin II receptor of the second type (AGTR2, -1332A/G, rs1403543 (G1675A)), angiotenzinoguena (AGT, rs4762 (Thr174Met), rs699 (M235T)).

Results. In children with CKD due to the VAMP not identified assotsiirovannymi with gene variants responsible for the progression of CKD. Children with CKD associated with glomerulonephritis have a significantly high incidence of allele With the AGT gene. Any genetic predisposition to arterial hypertension in the children studied by us was not revealed.

Conclusion. In children with VAMP, the risk of CKD progression is unrelated to genetic predisposition factors in the renin-angiotensin gene system.

Authors declare lack of the possible conflicts of interests.

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malformations of urinary system, children, genetic predisposition

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