Number №3, 2020 - page 72-78

Influence of urine pH on stone formation processes in urolithiasis DOI: 10.29188/2222-8543-2020-12-3-72-78

For citation: Prosyannikov M.Yu., Anokhin N.V., Golovanov S.A., Sivkov A.V., Apolikhin O.I. Influence of urine pH on stone formation processes in urolithiasis. Experimental and clinical urology 2020;(3):72-78. https://doi.org/10.29188/2222-8543-2020-12-3-72-78
Prosyannikov M.Yu., Anohin N.V., Golovanov S.A., Sivkov A.V., Apolihin O.I.
Information about authors:
  • Prosiannikov M.Yu. – PhD, Head of Department of urolithiasis of N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Centre of Radiology of the Ministry of Health of Russian Federation; SPIN-код: 3198-0030, https://orcid.org/0000-0003-3635-5244
  • Anokhin N.V. – PhD, Researcher of the Department of urolithiasis of N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Centre of Radiology of the Ministry of Health of Russian Federation; https://orcid.org/0000-0002-4341-4276
  • Golovanov S.A. – Dr.Sc., head of scientific Laboratory Department of N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Radiological Centre of the Ministry of Health of Russian Federation, https://orcid.org/0000-0002-6516-4730
  • Sivkov A.V. – PhD, Deputy Director on scientific work of N. Lopatkin Research Institute of urology and Interventional Radiology – branch of the National Medical Research Radiological Centre of Ministry of health of Russian Federation; https://orcid.org/0000-0001-8852-6485
  • Apolikhin O. I. – Dr. Sc., professor, Director of N. Lopatkin Research Institute of urology and Interventional Radiology – branch of the National Medical Research Radiological Centre of Ministry of health of Russian Federation; https://orcid.org/0000-0003-0206-043X
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Introduction. Urine pH is one of the key indicators to assess the activity of lithogenesis processes in urolithiasis patients. Urine pH is one of the significant markers signaling the presence of pathological changes both in the body as a whole and in the urinary system in particular. On the other hand, urine pH remains one of the key parameters that regulate the state of the urinary system and determine the type of metabolic lithogenic disorders.

The aim of the study was to assess the effect of urine pH on the formation of stones of various chemical composition and on the level of urinary excretion of the main stone-forming substances.

Materials and methods. The study examined data from 708 urolithiasis patients (303 men and 405 women). All patients underwent biochemical analysis of blood, biochemical analysis of daily urine, determination of the chemical composition of urinary stones.

Results. The incidence of uric acid urinary stones decreases as urine pH rises from 42.3% (pH1) to 2.6% (pH8) (p = 0.0000004). The maximum level of excretion of uric acid with urine was recorded in the urine pH range of 5.6-5.9 (pH4) and amounted to 3.814 mmol/day.

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urolithiasis; urine pH; stone formation; methaphilaxis.

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