Level of indicators in prooxidant-antioxidant equilibrium in children with hematuric form of chronic glomerulonephritis

Beglyarov R.O.

The goal is to study the intensity of LPO and AOS in children with a hematuric form of chronic glomerulonephritis. Methods. A total of 126 children were examined, of which the main group consisted of 96 children with the hematuric form of CGN, and the control group included 30 children without CGN. The average age is 12.06 ± 2.14 years. The stage of clinical remission was noted in 53 (55.2%), exacerbation of CGN – in 43 (44.8%) patients. Clinical, laboratory and instrumental methods of research have been applied. The levels of diene conjugates, malonic dialdehyde, reduced glutathione, catalase activity, glutathione peroxidase, glutathione reductase in blood plasma and erythrocytes were determined. Results. The content of DK in plasma and in erythrocytes practically did not differ from the control one. The concentration of MDA in both plasma and erythrocytes exceeded the reference level by 76.9% (p <0.01) and 58.3% (p <0.05), respectively, with higher MDA values in the active phase. Catalase activity is significantly decreased in erythrocytes (by 40.4%, p <0.05). The activity of GR in the plasma was reduced by an average of 42.9% (p <0.05), in erythrocytes – by 48.1% (p <0.05), the activity of GPO was reduced in plasma and in the control erythrocytes an average of 32.5% (p <0.05) and 32.1% (p <0.05), respectively. The GSH level was lower by 26.5% (p <0.05) and 43.9% (p <0.05), respectively, in plasma and in erythrocytes, compared with the control one. The minimum values of the AOS parameters were noted with aggravation of CGN. Conclusions. In children with a hematuric form of GI, there is an increase in the secondary product of LPO-MDA and a decrease in glutathione unit of AOS, especially pronounced in acute disease. A decrease in the content of GSH and a change in the activity of GPO and GR indicates a violation of the redox potential.

Author declare lack of the possible conflicts of interests.

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chronic glomerulonephritis, mixed form, kids, children, lipid peroxidation, antioxidant system, prooxidant-antioxidant balance

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