Modern concept of age-related androgen deficiency

Shestaev A.Yu., Protoschak V.V., Ashanina E.N., Iglovikov N.Yu., Kukushkin A.V., Kushnirenko N.P., Babkin P.A., Gul'ko A.M., Matich A.I., Karpuschenko E.G.

The article provides an overview of the current literature on the subject of the most common dishormonal status of men over 40 years old age-related androgen deficiency. To date, the criteria for setting VAD diagnosis, despite many studies remain controversial. It should be noted that the laboratory criteria of a low testosterone level is still causing debate in the scientific community because Various clinical manifestations of age-related androgen deficiency can be observed, including in the normal level of total testosterone. International Andrological Society and a number of other committees have determined that the boundary level of total testosterone is its value is less than 12 nmol/l, while the value of this index is less than 8 nmol/l may be an indication for hormone replacement therapy of testosterone. However, despite the relatively high prevalence of agerelated androgen deficiency, the urologist should not rely solely on laboratory parameters, as this condition may not be clinically manifestations asymptomatic. Results of the disease state, assessed the impact on operability, represented by the modern concept of the approach to diagnostic measures, including both laboratory research methods and validated scales for questioning. The problems of hormone replacement therapy, traditional and innovative forms of testosterone administration, its advantages and disadvantages.

Authors declare lack of the possible conflicts of interests.

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age-related androgen deficiency, testosterone, hormone replacement therapy, hypogonadism, partial androgen deficiency in aging men, operability