Number №1, 2019 - page 132-138

Prevention of infectious and inflammatory complications after percutaneous nephrolithotripsy using the drug pyobacteriophage10.29188/2222-8543-2019-11-1-132-138

Perepanova T.S., Merinov D.S., Kazachenko A.V., Tolordava E.L., Malova Yu.A.
Information about authors:
  • Perepanova T.S. – Dr. Sc., Head of the Department of infectious and inflammatory diseases and clinical pharmacology N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Radiological Centre of the Ministry of Health of Russian Federation; e-mail: perepanova2003@mail.ru; ORCID: 0000-0002-2877-0029
  • Merinov D.S. – PhD, Head of the Department of endourology of N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Centre of Radiology of the Ministry of Health of Russian Federation; e-mail: d.merinov@gmail.com
  • Kazachenko A.V. – Dr. Sc., deputy director for clinical work of N.A. Lopatkin Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Centre of Radiology of the Ministry of Health of Russian Federation; e-mail: avknii@mail.ru
  • Tolordava E.R. – PhD., Senior Researcher of N.F. Gamaleay National Research Center for Epidemiology and Microbiology of the Ministry of Health of Russian Federation
  • Malova Yu.A. – postgraduate student of N.A. Lopatkin Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Centre of Radiology of the Ministry of Health of Russian Federation; e-mail: avknii@mail.ru

Data on antimicrobial prophylaxis of infectious complications after percutaneous nephrolithotomy is presented in this article. The study was conducted among 60 patients with staghorn and multiple kidney stones who underwent percutaneous nephrolithotripsy (PCNL).

For prevention of infectious complications of PCNL pyobacteriophage preparation or antibiotic drug were used. Nephrostomic tubes and urethral catheters were treated with pyobacteriophage preparation for 30 minutes to hinder the formation of bacterial biofilms.

Tje study has shown that pyobacteriophage may be used for prevention and treatment of infectious complications of PCNL as an alternative to antibiotic prophylaxis, which is of great importance considering a rising prevalence of antibiotic-resistant strains. There was no difference in body temperature at 1, 3 and 7 days after the surgery, as well as in incidence of systemic inflammatory response between two groups. Moreover, 7 days after the surgery blood count parameters(white blood cells and banded neutrophils)were back to normal in all 4 groups, which leads to an assumption that antibiotics and bacteriophage preparations have equal efficacy.

Constant monitoring of microbial sensitivity to bacteriophage preparations and regularselection of bacteriophagesto pathogens of urological infection.

Authors declare lack of the possible conflicts of interests

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percutaneous nephrolithotripsy, urinary infection, pyobacteriophage

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