Number №3, 2019 - page 72-78

The rate of progression of malignant growth in patients with tumor diseases of the prostate, bladder, kidneys DOI: DOI: 10.29188/2222-8543-2019-11-3-72-78

Zaharova N.B., Ponukalin A.N., Komyagina A.N., Korolev A.Yu., Nikol'skiy Yu.G.
Information about authors:
  • Zakharova N.B. – Dr. Med. Sc., professor of department of clinical laboratory diagnostics of FSBEI "Saratov State Medical University named after V.I. Razumovsky "of Ministry of Health Of Russian Federation, lipidgormon@mail.ru, ORCID 0000-0001-9410-2240
  • Ponukalin A.N. – PhD, associate professor of department of urology of FSBEI «Saratov State Medical University named after V.I. Razumovsky» of Ministry of Health of Russian Federation, ponukalin@bk.ru, ORCID 0000-0003-2547-5654
  • Komiagina Yu.M. – applicant of department of urology of FSBEI «Saratov State Medical University named after V.I. Razumovsky» of Ministry of Health of Russian Federation, komiagina. jul@yandex.ru, ORCID 0000-0001-7603-1012
  • Korolev A.Yu. – PhD, assistant of department of urology of FSBEI urology of FSBEI «Saratov State Medical University named after V.I. Razumovsky» of Ministry of Health of Russian Federation, kay1973@bk.ru, ORCID 0000-0002-6763-8143
  • Nikolsky Yu.E. – assistant of the department of radiation diagnostics and radiation therapy named after prof. N.E. Stern of urology of FSBEI «Saratov State Medical University named after V.I. Razumovsky» of Ministry of Health of Russian Federation, yu480@yandex.ru ORCID 0000-0003-0258-5375
226

Contacts: Zakharova Natalia Borisovna, lipidgormon@mail.ru

Purpose of research. To establish the dependence of changes in the concentration of VEGF in blood serum in healthy individuals depending on the age and in patients with oncourological diseases in the progression of the disease.

Materials and methods. A survey of 76 healthy individuals and 303 patients with tumor diseases of the prostate(98),bladder(129), kidneys (98). When the diagnosis was confirmed, all patients underwent standard laboratory examination and instrumental examination. Serum concentrations of endothelial vascular endothelial growth factor (VEGF) were determined by solid-phase enzyme immunoassay.

Results. It was found that in patients with tumor diseases of the pancreas, bladder, kidneys diagnostic value increase VEGF serum levels compared with healthy individuals older than 41 years occurs at the stages of progression of tumor growth and development of metastases.

Discussion. IThe study of the level of VEGF in patients with cancer of the pancreas, bladder, kidneys can be recommended as an indicator of the activity of the metastatic process and an unfavorable prognosis of the disease.

Conclusions. With age, there is an increase in the content of VEGF serum in healthy individuals. Diagnostic value of the study of VEGF serum level in oncourological diseases becomes at the stage of progression of tumor growth, in the period of metastasis.

For citation: Zakharova N.B., Ponukalin A.N., Komyagin Yu.M., Korolev A.Yu., Nicholsky Yu.E. The rate of progression of malignant growth in patients with tumor diseases of the prostate, bladder, kidneys. Experimental and clinical urology 2019;(3):72-78

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kidney cancer, bladder cancer, prostate cancer, angiogenesis, vascular endothelial growth factor, biomarkers

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