Sensitivity of the major pathogens causing infectious- inflammatory diseases of the genitourinary system to a new antibiotic tigecycline

S.K. Y arovoy, L.N. Lavrinova,

N.S. Aleksandrov, A.V. Prokhorov

The article reports results of sensitiv­ity analysis to a new antibiotic tigecycline (group of glycyl-cyclines) of 1210 strains of the most common causative agents of infectious and inflammatory diseases of the genitourinary system. Biomaterial was taken from patients suffering from recurrent infectious and inflammatory diseases of the genitourinary system: secondary chronic pyelonephritis with a background of urolithiasis, neurogenic bladder dysfunction, abnormalities of the urogenital tract (965 pers. - 79.6%), chronic prostatitis (154 pers. - 12.7%), secondary chronic cystitis (91 - 7.5%). The highest activity of the antibiotic was noticed against Enterococcus spp., Staphylococcus spp., Streptococcus spp., including multidrugresistant hospital strains of MRSA, VRSA, VRE. No tigecyclineresistant strains have been identified among the selected grampositive bacteria.

E. coli, Klebsiella spp., Proteus spp, and other more rare gramnegative pathogens also demonstrated a high level of sensitivity to tigecycline - up to 95.5%. Indications for tigecycline as antibiotic therapy were determined: the mixed infection, vancomycinresistant strains of gram-positive pathogens and antibiotic prophylaxis in penile prosthesis operations, treatment of periprosthetic infection, acute cavernitis, hematogenous abscesses of kidney and prostate with the background of staphylococcus infection. We described a clinical case of successful conservative treatment of acute periprosthetic infection after penile prosthesis operation. In the inefficiency of glycopeptides and carbapenems inflammatory process was stopped by tigecycline.