Sodium hypochlorite and Selye common adaptation syndrome.

Ivaschenko V.V., Kirpatovskiy V.I., Chernyshev I.V., Kudryavcev Yu.V., Perepanova T.S., Nikonova L.M., Pen'kov P.L.

The paper is dedicated to the mechanism of adaptogenic effect of sodium hypochlorite (SH). The studies were performed in three groups of 45 albino male rats. Group of intact animals were 5 rats. The rats in the control group (n = 20) were daily intraperitoneally (i / p) administered for 1.5 ml of saline for 4 days. The rats in the experimental group (n = 20) were similarly injected with 1.5 ml 0.06% solution of SH. The results in the group of intact rats were considered the normal values. The animals were taken from the experiment at 1st, 4th and 7th days after injection of SH. The levels of adrenocorticotropic hormone, thyroid-stimulating hormone, growth hormone, parathyroid hormone, cortisol, aldosterone, testosterone, adrenaline, noradrenaline, dopamine, serotonin, insulin, renin were measured. Complete blood count indicators were monitored. Stomach and adrenal glands were removed for histological examination.

1 hour after injection of saline and 0.06% solution of SH, on the 1st, 4th and 7th day of control no activation of the pituitary-adrenal system have been identified. In the experimental group showed a significant decrease in cortisol levels after 1 hour of observation and on the 7th day, ACTH was significantly lower than in controls at 1 hour and on the 1st day of observation. Catecholamine levels did not significantly change. In the study of adrenal no lipid reduction in the cortical layer and no increase adrenal cortex were found. Macroscopic examination of the gastric mucosa showed no signs of erosive and ulcerative process. Thus, the SH at doses that violate the constancy of the internal environment of the body, does not cause a H. Selye general adaptation syndrome. 

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