Teratozoospermia and karyopathologiсal effects in blood cells in Western Siberians infected with anaplasma (Anaplasma phagocytophilum)

Il'inskih N.N., Il'inskih E.N., Kostromeeva M.S.

Introduction. Anaplasmosis is an acute febrile disease transmitted by vectors which are the Ixodidae ticks. Experiments on animals have shown the ability of this infectious agent to cause cytogenetic damage and pathological alternations of spermatogenesis.

Purpose. The aim of this work is to study the role of human granulocytotropic anaplasmosis (HGA) caused by Anaplasma phagocytophilum in the karyopathological effects in blood cells and in the teratozoospermia in the inhabitants of Western Siberia.

Material and methods. There were included in the study a group of 16 HGApatientswhowere examined triply (at the beginning of the disease, a month and 3 monthslater), aswell as 18 asymptomatic A. phagocytophilum carriers and 14 healthy blood donors who were examined once. Samples of both the sperm of the ejaculate and the peripheral blood were obtained from each individual for microscopic analysis.

Results. Cytological analysisrevealed the significantly high frequencies of karyopatological effects in monocytes, neutrophils and erythrocytes of the peripheral blood of HGApatients.e detection higherfrequencies of micronuclei among the types of cytopathology can confirm the idea of the increased levels of chromosomal damage in these cells of HGApatients. Moreover, the significantly high frequencies of the teratozoospermia including pathological morphology of the head and the neck of spermatozoa were revealed in both of the patients and the asymptomatic anaplasma carriers.

Conclusion. The data were allowed to conclude that significantly high frequencies of karyopathological effects in the blood cells and the spermatozoa can be induced byA. phagocytophilum.ese effectswere persisted during a month in the group of patients. These results were become indistinguishable from the data of the control only in 3 months aer the onset of the disease.

Authors declare lack of the possible conflicts of interests.

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human granulocytotropic anaplasmosis, teratozoospermia, karyopathology, blood cells

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