Аполихин О.И.

Over the past 20 years a large number of prostate cancer (PCa) markers have been proposed. A combination of PCA3 and TMPRSS2-ERG is among them. The real-time RT-PCRbased method for РСА3 and TMPRSS2-ERG determination in urine and prostate tissue is being developed at Russian Scientific-research Institute of Urology. Purposely to assessment of its diagnostic value, two independent samples of prostate tissue (n=78) and urine (n=56) specimens were investigated. The blood level of PSA, pathomorphological findings, PCA3 and TMPRSS2-ERG urinary and tissue expression were assessed.

Economical efficacy of the prostate cancer screening in the Russian Federation was estimated using the modeling of three healthcare systems based on the official statistical data and the modern evidence from the major publications.

We have performed a comparative retrospective analysis of the urological (including the oncourological) morbidity in a period of 10 years (2003-2013) according to official medical statistics. The aim was the objective investigation of the urological service in Russia and it’s regions. Structure of the urological diseases, oncourological diseases of the bladder, prostate and kidney, and although the associated mortality were evaluated for this period.

Nowadays the erectile dysfunction is considered the key point in understanding of the mechanisms of development and progression of cardiovascular diseases. The number of patients with risk factors of cardiovascular diseases increases together with the worldwide frequency of sexual disorders. Every year about 17 million people die of cardiovascular diseases. During the last decades various surgical and endovascular methods of treatment of this pathology have been actively used.

A constant upwards trend is observed in Russian federation with regard to the bladder cancer (BCA) incidence. Early diagnostics plays a crucial role for the treatment efficacy. Biomarkers are contemporary used for diagnostics with some substances considered to be feasible for this application (tumor antigens, proliferation, adhesion and angiogenesis markers, etc.) More than 10 test systems were integrated in the clinic, which were more effective than urine cytology (UC), but nevertheless had some limitations.

Introduction. Distance medical education is a today’s reality. Medical specialists should use nowadays the newest and the most actual knowledge in their work. This article outlines the development and application of the Distance Education Program for primary care physicians.

The most common pathogenetic factor for erectile dysfunction is a vascular lesion, and it is often systemic disease. Therefore, the identification of vascular origin of erectile dysfunction can be a reason for comprehensive examination of the cardiovascular system. The lack of published data on the connection between arteriogenic erectile dysfunction and cardiovascular disease caused of the organization of our study. We examined 481 adult male with complaints of erectile dysfunction.

In this article we present the results of the analysis of structure and dynamics of the pediatric morbidity with regard to the urogenital diseases for the patients with the age of 0-17 years in the city of Stavropol according to the documental form of the federal statе statistic control №12 «Information to the frequency of diseases in patients from the healthcare district» (further referred as Form 12).

The prostate cancer (PCa) is nowadays one of the most common and progressively growing diseases in the area of oncourology. The yearly growth of the PCa incidence is 3%. The screening introduction was not effective, leading to the new problems with overdiagnosis, overtreatment and corresponding financial burden and growth in number of complications. As a result of this a new complex staged standardized program was developed in the National Scientific Institute of Urology for the treatment of patients with prostate cancer, which was introduced in Voronezh district in 2010.

In this study we have evaluated the link between the urolithiasis and burdened familial history and single nucleotide polymorphisms (SNP) of the candidate genes without familial anamnesis. We have investigated 125 adult patients with urolithiasis (main study group) from Central Russia and 188 healthy adults from the same region (control group).