EXPERIMENTAL UROLOGY

Introduction. In previously published experimental studies, we have shown that in rats with pre-modeled acute post-ischemic renal failure, therapy with a proteomic complex isolated from brain cells of pig embryos has a pronounced therapeutic effect, reducing the severity of functional and histological disorders and preventing the transition of the pathological process into chronic kidney insuffiency. The aim of this study is to evaluate the effectiveness of this therapy for the course of artificially induced chronic renal failure (CRF) in rats.

Introduction. The male factor in infertile marriages accounts for about 50% of all cases, which is associated with changes in the characteristics of the ejaculate microbiota and directly correlates with changes in sperm parameters, including sperm count, motility, and morphology.

Introduction. The review is devoted to the analysis of the world experience in the use of artificial intelligence in medicine and urology.

Materials and methods. The review was conducted on the basis of data published in the PubMed, Scientific Electronic Library eLibrary.ru databases and on the professional medical associations websites. The article contains 43 scientific publications.

Introduction. Traditionally it is believed that the therapeutic effect of the hexane extract of Serenoa repens (HSRE) in patients with benign prostatic hyperplasia is realized due to its effect on prostate cells. However, in the literature there is data about the possible HSRE effect not only on the prostate, but also directly on the bladder. This paper summarizes data and analyzes the possible cellular mechanisms of HSRE action on the bladder under the development of infravesical obstruction (bladder outlet obstruction – BOO).

Introduction. Percutaneous surgery is one of the methods of surgical treatment of renal stones. The most difficult stage of the operation is the creation of percutaneous access to the pyelocaliceal system of the kidney. To facilitate access under ultrasound (US) guidance, it is customary to use a needle guide which is fixed to the US-probe. Taking into account the sanctions of the equipment manufacturing countries, Russian specialists may potentially find themselves in conditions of a shortage of components and particularly needle guide for ultrasound probes.

Introduction. It is believed that the «target» of the hexane extract of Serenoa repens (HESR) is the prostate gland itself. However, there is evidence in the literature that the therapeutic effect of HESR can be carried out at the level of the bladder. We hypothesized about the direct effect of HESR on the obstructive bladder, preventing the development of its dysfunction.

Introduction. The use of peptides that penetrate the cell without the participation of membrane proteins and are capable of intracellular transport of low molecular weight substances associated with them opens up a new stage in the development of targeted drug delivery to therapeutic targets.

Aim. Evaluation of the effect of prostatic peptides of Vitaprost^® (prostate extract) on the transmembrane transport of the antimicrobial drug lomefloxacin.

Introduction. Male infertility is one of the main causes of forced childlessness of couples around the world. Currently, a limited number of drugs for the treatment of male infertility are available on the market. Biologically active supplements (dietary supplements) containing L-carnitine are often used in the complex therapy.

Introduction. Currently, the possibilities of cell therapy using stem cells for the correction of functional disorders of organs, including kidneys, are being widely investigated. The main mechanism of action of stem cells is considered to be the activation of cellular regeneration and the inhibition of apoptosis by the products of their secretion (secretome), which makes it necessary to study the mechanisms of action of the stem cells secretome.

Introduction. Cystatin C is one of the markers of acute kidney injury, which have a greater sensitivity than the level of blood creatinine. There are separate publications that the dynamic determination of the level of cystatin C in the blood can be useful for predicting the course of the pathological process and the risk of transition of acute injury (AKI) to chronic kidney disease (CKD).