EXPERIMENTAL UROLOGY

Introduction. Chronic ischemia is an important pathogenic factor of urination disorders in patients with benign prostatic hyperplasia (BPH). The aim of this study was to investigate the rationale for administering the drugs with anti-ischemic action in order to improve the urinary bladder function after acute urinary retention (AUR).

Aim is to study, compare and identify the possible interrelations between the homeostasis disorders of the systemic (blood) and organ (in the prostate gland)levelsin various experimental models of chronic abacterial prostatitis (CAP) III-B.

Objective. Experimental study of the effect of sodium hypochlorite (SH) on renal function and hormonal status intact rats, influencing the composition of the final urine.

Aim: To prove the safety of bypass surgery on fetal kidneys by studying pathomorphological changes in fetal kidneys of laboratory animals by the use of a stent developed in the Federal State Budgetary Institution “Urals Scientific Research Institute for Maternal and Child Care” of the Ministry of Healthcare of the Russian Federation, Yekaterinburg (FSBI «USRIMCC»). The stent was designed for fetal kidney bypass surgery in obstructive congenital disorder of the urinary system.

In order to create an experimental model of benign prostatic hyperplasia (BPH), rats aged 16-18 months received sulpiride (40 mg per 1 kg of weight) during a 30-day period. 10 days after the final injection, the relative mass of the dorsolateral lobes of the prostate was twofold higher, the volume of the glandular tissue increased by 25%, and the thickness of the epithelial layer of the prostate increased 1.6-fold (the numbers are provided in comparison with the control level).

Clinical proteomics is one of the directions of the development of methods of personalized medicine, since it takes part in revealing the biological markers of different diseases. The incorporation of immunoassays into the methods of clinical assessment has demonstrated that a series of urinary proteins may be used for the evaluation of the renal parenchyma, urinary tracts, cardiovascular diseases, etc. Mass-spectrometry is a new and one of the most powerful technologies used for the search for biomarkers, which can obtain information about hundreds of proteins simultaneously.

The aim of the research. The estimation of the effectiveness of biodegradable stent on the basis of polyhydroxyalcanoates for pyeloureteral segment plastic surgery.

Materials and methods. Stenting of rabbits’ ureter after pyeloureteral segment plastic surgery with the use of stents from polyurethane and polymeric stents from 3-hydroxybutyrate and 

The aim of the research. Experimental study of the sodium hypochlorite (SH) effect on the blood and urine electrolyte composition, cations and anions, that are part of the urinary stones, which are recognized risk factors for urolithiasis.

Introduction. Benign prostatic hyperplasia and associated diseases develop significantly more often in patients with metabolic syndrome (MS) in comparison with a general male population of the same age. The pathogenesis of these conditions requires a special research.

Introduction. The use of internal stents, in order to maintain the lumen of the hollow body, has become widespread in the different sections of surgery, including urology. However, there are negative aspects of the use of internal drainage. Unattainable full bioinertness, direct mechanical effect on the body wall leads to the inflammatory edema, disruption of the microcirculation and peristalsis. Available objective disadvantages of internal stents are pushing the development of structures and the search for materials for the production of stents