гиперактивность мочевого пузыря

The experiments were made using 20 mature male rats (line “August”) with a mass of 280-320 g. In 10 rats metabolic changes typical for metabolic syndrome (MS) were induced using high-calorie diet (adding of 20% margarine to standard diet and 20% of fructose to the water during 3 months), bilateral orchiectomy (to create androgen deficiency) and stress (immobilization stress during 1 day in the end of the observation period).

Overactive bladder (OAB) prevalence is a quite high and is 16-22% among adults. In addition, significance of OAB is explained not only by high prevalence but also substantial quality of life decrease in these patients. Recently a lot of attention is paid to ischemia and related microcirculation disorder in bladder wall.