рак мочевого пузыря

More than 13 thousand cases of bladder cancer are registered in Russia annually that represents an actual problem in modern urologic oncology. Searching and characterization of new molecular markers of non-muscle invasive bladder cancer (NMIBC – 80% of bladder cancer cases), identified in tumor cells from urine sediment are needed. We have provided complex analysis of mutations in the key oncogenes of NMIBC using PCR and subsequent sequencing of exons 7 and 10 of the gene FGFR3, exons 9 and 20 of the gene PIK3CA.

A bladder cancer (BC) – oncologic disease with wide range of risk factors. A trigger of the most of oncological diseases is an individual genetic predisposition provoked by various environmental factors, first of all of chemical nature. Various cancer causing agents that are collectively known as xenobiotics refer to the risk factors for BC. Necessary condition for manifestation of xenobiotics action is a hypersusceptibility that appears in the presence of certain genetic background.