Pathogenetic role of the chronical bacterial prostatitis in the development of androgen deficiency in fertile patients

Antonov K.K., Erkovich A.A., Cyrendorzhiev D.D., Kuznecova N.N., Farbirovich V.Ya., Kurbanaliev R.M.

Nowadays the data revealing relationship between chronic bacterial prostatitis (CBP) and androgen suppression is lacking. The aim of the study was to provide the pathogenetic explanation of the CBP role in the development of the androgen deficiency (AD) in fertile patients.

We have studied the relationship between the CBP and levels of pro-inflammatory cytokines – TNF-alpha, IL-1-beta and IL-4 – in the ejaculate of the patients with AD, and also the relationship between the levels of these substances and androgen state after the CBP treatment.

The patients with CBP demonstrated the decreased levels of total testosterone, bio-available testosterone and free testosterone, which is associated with the overproduction of the IL-1 and TNF-alpha.

Statistically significant increase in total testosterone concentration was shown to correspond with the decrease in the pro-inflammatory cytokines concentration and in the number of leukocytes.

Our results show that androgen deficiency in patients with CBP could be due to the overproduction of the pro-inflammatory cytokines (IL-1 and TNF-alpha), which affect the patients with long-lasting history of the disease.

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