Use of chorionic gonadotropin as a hormonal stimulating therapy in patients with pathospermia

Efremov E.A., Hizriev H.Z., Kastrikin Yu.V., Butov A.O, Tolstov I.S.

At the present time, there is no consensus regarding the optimal approach to fertility treatment in men. Per the literature considered that increase of level of gonadotropins induce spermatogenesis and is essential for maintenance of quantitatively and qualitatively normal spermatogenesis. Such treatment uniformly successful in normalizing release of gonadotropins and secretion of testosterone which is capable to induce a spermatogenesis. This paper reviews recent literature to summarize the current evidence on therapeutic approaches for hypogonadotrophic hypogonadism men with pathospermia seeking fertility. We conclude that hormonal treatment with human chorionic gonadotrophin is well tolerated and effective in inducing testis growth, spermatogenesis and fertility in men with hypogonadotropic hypogonadism. In most cases, appropriate hormonal treatment with human chorionic gonadotrophin increase in quantity of spermatozoa and increase in the general mobility and in certain cases increase in percent of morphologically normal forms of spermatozoa. However, regarding eliminating oligoteratozoospermia and achieve spontaneous conception proved to be the most effective combination of hCG therapy with rFSH.

Authors declare lack of the possible conflicts of interests

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hypogonadism, gonadotropins, male infertility, spermatogenesis, pathospermia

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