Protective action of the anti-ischemic therapy with alpha-adrenoblockers on experimental infravesicalthe bladder obstruction

Kirpatovskiy V.I., Mudraya I.S., Golovanov S.A., Drozhzheva V.V., Adamyan N.K., Ivanov V.P., Frolova E.V.

In this experimental work on 28 female inbreed rats we have studied the action of the complex of anti-ischemic medications (alpha-tocopherol, trental, mexidol and diltiazem in a daily dosage 10 mg/kg, 4 mg/kg, 5 mg/kg and 2 mg/kg, correspondingly) and alpha-adrenoblocker doxazosin in a daily dosage 0.05 mg/kg with the background of the modelled infravesical obstruction via the dosed compression of the infravesical urethra. In the control series (without treatment) we have observed a significant deterioration of the blood supply to the obstructed bladder, which was accompanied by the increases in the enzyme activity (ALT, AST, LDH, CPK) in the urine and decrease in the activity in the bladder wall, which was a sign for prominent cell damage, including damage to the smooth muscle cells of the detrusor. Spontaneous changes in the intravesical pressure were observed in the filling phase, meaning the detrusor hyperactivity. Therapy with the complex of anti-ischemic medications in similar conditions led to the preservation of almost normal blood supply and significant less expressed enzymerelated shift from bladder wall to the urine. The amplitude of spontaneous fluctuations in intravesical pressure was low and similar to that in healthy animals. Therapy with doxazosin was also related to the decrease in the functional and metabolic disturbances, linked to the infravesical obstruction, to the subnormal level; at that indices of the bladder blood supply were worsened. Combination therapy with doxazosin and anti-ischemic complex did not increase the level of the bladder protection, when compared to the anti-ischemic complex and doxasosine alone. 

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infravesical, obstruction, chronic bladder ischemia, ,doxasosine, antiichemic therapy, alpha-adrenoblockers