Ибрагимов А.Р.

We investigated regional neurogenic activity and microcirculation state in 5 patients before botulinum toxin injection (Lantox) into detrusor and bladder sphincter and 1-4 days after injection.

A new method of the harmonic analysis of bioimpedance microvariations (approved earlier in the experimental studies) was effectively used to estimate the regional rhythmic activity (due to neurogenic, sympathend parasympathetic influence) and vascular activity during treatment.

Effects of botulinum toxin injection into detrusor on autonomic regulation were studied in normal and after 1 month of infravesical obstruction modeling. Investigations were made in acute experiments during infusion cystometry, in which synchronous registration was performed of detrusor pressure and bladder impedance with highly sensitive soft and hardware complex (“Biola”).