Introduction. The combination of erectile dysfunction (ED) and premature ejaculation (PE) requires an integrated therapeutic approach.
Purpose of study. Compare the efficacy of tadalafil monotherapy and combination therapy with rhythmic peripheral magnetic stimulation (rPMS).
Materials and methods. A prospective randomized study included 29 patients with ED and PE, divided into two groups: Group 1 (n=14) received tadalafil 5 mg/day, while Group 2 (n=15) received tadalafil 5 mg/day combined with rPMS (15 sessions). Efficacy was evaluated after 6 weeks based on changes in the International Index of Erectile Function (IIEF-5), Premature Ejaculation Diagnostic Tool (PEDT), intravaginal ejaculatory latency time (IELT), and subjective visual analog scale (VAS) scores for patient (VAS 1) and partner (VAS 2) satisfaction.
Results. Group 2 demonstrated significantly greater improvement across all parameters: ΔIIEF-5 +10.4±1.4 vs. +5.4±1.1 (p<0.001), ΔPEDT -5.0±0.9 vs. -2.0±0.8 (p<0.001), and ΔIELT +104.6±8.5 sec vs. +36.2±6.8 sec (p<0.001). Partner satisfaction increased by 4.07±3.27 points in Group 2 compared to 3.33±2.99 in Group 1 (p<0.001).
Conclusion. The obtained data indicate a more pronounced positive change in the main clinical parameters in the combination therapy group. Improvements in IIEF-5 and PEDT scores, an increase in IELT, as well as greater subjective satisfaction among both patients and their partners, allow rhythmic peripheral magnetic stimulation (rPMS) to be considered a promising adjunct to standard PDE-5 inhibitor therapy in this patient category.
