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Spermatogenesis and sexual function in patients after high-dose brachytherapy for prostate cancer DOI: 10.29188/2222-8543-2025-18-3-58-65
- Akramov M.M. – postgraduate student of the Department of Urology and Operative Nephrology with a course in oncourology, RUDN University; Moscow, Russia;https://orcid.org/0000-0002-5904-9859
- Krasnyak S.S. – PhD, Leading Researcher of Department of Andrology and Human Reproduction of N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Centre of Radiology of the Ministry of Health of Russian Federation; Moscow, Russia; RSCI Author ID 641107, https://orcid.org/0000-0001-9819-6299
- Perepukhov V.M. – junior Researcher, Department of Oncourology of N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Centre of Radiology of the Ministry of Health of Russian Federation; Moscow, Russia; RSCI Author ID 1227782, https://orcid.org/0000-0001-7280-2553
- Koryakin A.V. – PhD, Head of the Innovation Department of N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Centre of Radiology of the Ministry of Health of Russian Federation; Moscow, Russia; RSCI Author ID 636115; https://orcid.org/0000-0001-6595-8234
- Kazachenko A.V. – Dr. Sci., Deputy Director for Medical Work of N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Centre of Radiology of the Ministry of Health of Russian Federation; Professor of the Department of Urology and Operative Nephrology with a course of oncourology of RUDN University, Moscow, Russia; RSCI Author ID 334714, https://orcid.org/0000-0003-3198-5933
101 Introduction. Prostate cancer (PCa) is the most frequently diagnosed oncological disease in men in Russia. In the early stages of localized low- and intermediate risk PCa, radical prostatectomy or various methods of radiation therapy are performed, both approaches demonstrate similar oncological results. The number of cases of PCa at a younger age is increasing, which makes functional outcomes increasingly relevant issues when choosing a treatment approach, in particular, preserving erectile function, and according to some data, fertility.
The aim of this review is to evaluate and compare the effect of high-dose-rate brachytherapy with other methods of radical treatment of prostate cancer on sexual function and fertility.
Materials and methods. A search and analysis of publications in scientific databases PubMed, Scopus, Web of Science, eLibrary was performed using the following keywords: prostate cancer, high-dose-rate brachytherapy, low-dose-rate brachytherapy, functional outcomes, erectile function, dysfunction, fertility. A total of 65 publications were selected for this review.
Results. The article presents data on the mechanisms of radiation-induced impairment of spermatogenesis, the state of spermatogenesis in patients with PCa after brachytherapy, and the effect of high-dose and low-dose brachytherapy on the sexual function of patients.
Conclusions. According to a number of studies, systematic reviews and meta-analyses, high-dose-rate brachytherapy demonstrates the best functional indicators in terms of erectile function and fertility.
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