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Introduction. The problem of urolithiasis (ICD) retains its high relevance throughout the world due to the high prevalence among the population, frequent recurrences of the disease.
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Phosphodiesterase type 5 inhibitors (iPDE-5) are the first line medications for erectile dysfunction in men. Given that all of them are highly selective, nevertheless they can have effects on the other isoforms of phosphodiesterase (including type 11), which are located in different tissues. Some experimental works show that influence on PDE-11 could affect spermatogenesis. Nevertheless, there is no common opinion whether if fertility affected or not and how.
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In scientific research institute of urology of Russian health care department unified recommendations schemes of urate, calcium-oxalate and calcium-phosphate calculi formation prophylaxis were developed and already used for many years. They reflect tactics of management of stated groups of patients, contain information of chemical structure of calculi removed or drawn off by itself, disorders of lithogenous compounds exchange, which were the basement of scheme development. To evaluate the efficacy of long-term outpatient treatment of patients due to these sch
