Беспалов В.Г.

Contacts: Vasilieva Irina Nikolaevna, iravasilyeva@hotmail.com Introduction. Extracellular DNA (ecDNA) is considered to be a biomarker of cell death in diagnostics of prostate diseases. Aim – To assess concentration of ecDNA in blood of young and elderly rats in normal conditions and in induced benign prostatic hyperplasia (BPH).

Effect of a coniferous provitamin concentrate (CPC) on the development of benign prostatic hyperplasia (BPH) in comparison with extract of Serenoa repens fruits was studied. BPH was induced by daily intraperitoneal administrations of sulpiride at a doze of 40 mg/kg of body weight for 40 days in male Wistar rats. CPC or extract of Serenoa repens at dozes of 400 and 200 mg/kg of body weight, accordingly, were given to rats by intragastric tube simultaneously with the administration of sulpiride.

Two new modifications of a combined two-phasic model of the prostate carcinogenesis are developed. Experiments were carried out in 86 Wistar male rats.

Review of clinical and experimental data on medications, nutritional and non nutritional substances, that able to slow down cancerogenesis in prostate. Review and classification of medications and substances inhibiting prostate cancerogenesis in clinical and preclinical trials with perspective of further investigation and practical application as a prostate cancer chemoprophylaxis option.