Effect of a coniferous provitamin concentrate (CPC) on the development of benign prostatic hyperplasia (BPH) in comparison with extract of Serenoa repens fruits was studied. BPH was induced by daily intraperitoneal administrations of sulpiride at a doze of 40 mg/kg of body weight for 40 days in male Wistar rats. CPC or extract of Serenoa repens at dozes of 400 and 200 mg/kg of body weight, accordingly, were given to rats by intragastric tube simultaneously with the administration of sulpiride. In comparison with the control animals received sulpiride alone CPC significantly decreased the mean relative weight of the dorsolateral, ventral, and anterior prostate as well as of the whole prostate on 28.9%, 31.8%, 32.7% and 29.7%, accordingly. Therapeutic effect of CPC on BPH was more expressed compared with extract of Serenoa repens. It is reasonable to continue further studying of CPC as promising replacing import phytomedicine for the treatment of early stages of BPH in men.