Some aspects of the pathogenesis of urolithiasis

Number №3, 2024 - page 128-133

DOI: 10.29188/2222-8543-2024-17-3-128-133

For citation: Semenychev D.V., Semenycheva L.L., Mitin A.V., Knutov A.V., Kochkin A.D., Sevryukov F.А. Some aspects of the pathogenesis of urolithiasis. Experimental and Clinical Urology 2024;17(3):128-133; https://doi.org/10.29188/2222-8543-2024-17-3-128-133

Semenychev D.V. Semenycheva L.L. Mitin A.V. Knutov A.V. Kochkin A.D. Sevryukov F.A.

Information about authors:

Semenychev D.V. – PhD, assistant professor of the Department of Urology of the Faculty of Additional professional education, FSBEI «Privolzhsky Research Medical University» MOH of the Russian Federation, Urologist, Urology Division, Nizhny Novgorod Clinical Hospital «Russian Railways-Medicine»; Nizhny Novgorod, Russia; RSCI Author ID 897736, https://orcid.org/0000-0002-2804-9020
Semenycheva L.L. – Dr. Sci., Head of Research Laboratory, Lobachevsky State University of Nizhny Novgorod; Nizhny Novgorod, Russia; RSCI Author ID 44529, https://orcid.org/0000-0003-3413-2899
Mitin A.V. – PhD, Head of Research Laboratory, Lobachevsky State University of Nizhny Novgorod; Nizhny Novgorod, Russia; RSCI Author ID 131842, https://orcid.org/0009-0009-5594-6868
Knutov A.V. ‒ PhD, assistant professor of the Department of Urology of the Faculty of Additional professional education, FSBEI «Privolzhsky Research Medical University» MOH of the Russian Federation, Urologist, Urology Division, Nizhny Novgorod Clinical Hospital «Russian Railways-Medicine»; Nizhny Novgorod, Russia; RSCI Author ID 1006917, https://orcid.org/0009-0006-3993-7011
Kochkin A.D. ‒ Dr. Sci., head of the Department of Urology of the Faculty of Additional professional education, FSBEI «Privolzhsky Research Medical University» MOH of the Russian Federation, Urologist, Urology Division, Nizhny Novgorod Clinical Hospital «Russian Railways-Medicine»; Nizhny Novgorod, Russia; RSCI Author ID 526782, https://orcid.org/0000-0002-7242-377X
Sevryukov F.A. ‒ Dr. Sci., Professor at the E.V. Shakhov Department of Urology, FSBEI «Privolzhsky Research Medical University» MOH of the Russian Federation; Nizhny Novgorod, Russia; https://orcid.org/0000-0001-5120-2620

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Introduction. Urolithiasis is a disease whose etiology and pathogenesis have not been fully elucidated. However, studies of recent decades indicate the presence of an organic matrix in the composition of all urinary stone.

Materials and methods. A white substance of the consistency of «soft plasticine» was extracted from the pelvis of the right kidney. The sample was examined for elementary composition, molecular weight characteristics and structure.

Results. The structure of the sample had a fibrillar structure and was a mixture of various proteins and glycoproteins. The sample extracted from the kidney consists of 70% of inflammatory and transport proteins (myelopyroxidase, immunoglobulin, calprotectin), and 30% is a hard-to-dissolve polymer (polymerized Tamma-Horsfal protein).

Conclusions. The formation of large and coral kidney stone can begin with the formation of a «matrix model» consisting of various proteins, mainly involved in inflammation, followed by mineralization and compaction of the stone.

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Keywords: urolithiasis; pathogenesis; urinary stones formation; protein matrix; urolit mineralization

Some aspects of the pathogenesis of urolithiasis

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