Introduction. In patients undergoing transurethral resection of the prostate for benign prostatic hyperplasia, lower urinary tract symptoms associated with overactive bladder often persist in the postoperative period. The search for effective conservative treatment regimens for this category of patients remains a relevant clinical issue.
The aim of the study was to evaluate the efficacy of combination therapy with tamsulosin and Vesustin® in patients with overactive bladder symptoms after transurethral resection of the prostate for benign prostatic hyperplasia.
Materials and methods. This prospective clinical study included 30 men who had undergone transurethral resection of the prostate and complained post-operatively of frequent low-volume urination, a sensation of incomplete bladder emptying, nocturia, and urgency, including episodes accompanied by urge urinary incontinence. The patients were randomized into two equal groups. The control group received tamsulosin, whereas the experimental group received combination therapy with tamsulosin and Vezusten. Treatment efficacy was assessed based on changes in clinical symptoms and the results of patient questionnaires using the OAB-q.
Results. During therapy, statistically significant reductions in the severity of urinary urgency and frequency were observed in both groups. However, the average LUTS urgency component score, obtained from patient surveys using the OAB-q questionnaire, decreased 1.6 times more in the experi¬mental group than in the control group. Furthermore, a statistically significant reduction in the nocturia component score was observed in the experimental group compared to the control group.
Conclusion. The inclusion of Vezusten in the combination therapy of lower urinary tract symptoms associated with overactive bladder in patients after transurethral resection of the prostate was associated with a more pronounced clinical effect compared with tamsulosin monotherapy. The findings suggest that this regimen may be considered a promising option for postoperative management in this category of patients.
