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Active surveillance for intermediate-risk prostate сancer DOI: 10.29188/2222-8543-2022-15-3-55-63
- Kokin S.P. – post-graduate student, N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiological Center of Ministry of Health of Russia; Moscow; Russia; https://orcid.org/0000-0002-9783-7530
- Nyushko K.M. – Dr. Sci., head of the oncourology department N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiological Center of Ministry of Health of Russia; Medical Institute of Continuing Education, Moscow State University of Food Production; Moscow; Russia; https://orcid.org/0000-0002-4171-6211
- Alekseev B.Ya. – Dr. Sci., Professor, Deputy General Director for Research; National Medical Research Radiological Center of Ministry of Health of Russia, Medical Institute of Continuing Education, Moscow State University of Food Production; Moscow; Russia; https://orcid.org/0000-0002-3398-4128
- Mailyan O.A. – post-graduate student, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia; Moscow; Russia; https://orcid.org/0000-0002-9787-8842
363 Introduction. Prostate cancer (PСa) is one of the most common malignant diseases in men in the world. Radical prostatectomy remains the «gold standard» for treating this pathology. Good long-term oncological results Active follow-up of low-risk patients, as well as modification of the Gleason scale, suggested the possibility of using AS in carefully selected patients with intermediate-risk PCa. The introduction of molecular genetic markers into practice will allow a personalized choice of a treatment method.
Purpose. Conduct a systematic review of the literature on the analysis of active surveillance in patients with PCa of an intermediate risk group, existing molecular genetic markers for additional risk stratification.
Materials and methods. A systematic review of publications on active surveillance in prostate cancer, published in the PubMed, Cochrane, e-Library databases, was performed. Databases were searched using the following keywords: active surveillance, prostate cancer, intermediate risk, molecular genetic markers.
Results. This review selected 39 articles, of which 24 are devoted to Active Surveillance, 15 molecular genetic markers of PCа aggressiveness. In the analysis of active surveillance, parameters such as the percentage of patients without active (radical) treatment, overall survival, tumor-specific survival, and metastasis-free survival were evaluated.
Conclusions. Currently, AS in prostate cancer can be used for carefully selected group of patients at an intermediate risk group, the introduction of modern molecular genetic markers will allow more accurate determination of the amount of treatment without worsening long-term oncological results.
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