Aim. To evaluate the effectiveness of the impact of hypercapnic hypoxia on prostate microcirculation in patients with chronic abacterial prostatitis (CAP).

Materials and methods. Forthe evaluation of the impact of hypercapnic hypoxia on prostate blood flow in patients with CAP, we examined 39 male patients aged 20-50 and divided them into two groups. The first group consisted of 18 patients (46%), who were receiving only basal therapy comprising daily administration of one pill of levofloxacin (Tavanic), one capsule of tamsulosin (Omnic), one capsule of Serenoa repens extract (Prostamol Uno), one sachet of nimesulide (Nimesil) 1-2 timer per day and rectal administration of one suppository of Samprost. e basal therapy was prescribed according to clinicalrecommendations developed by the Russian Urological Society and the Association of Medical Societies for Quality.

The second group consisted of 21 patients (54%), whose treatment, apart from the basal therapy, included respiratory exerciseswith the effect of hypercapnic hypoxia (10 sessions during the course). Such exerciseslead to the increase in the partial pressure of carbon dioxide and to the decrease in the partial pressure of oxygen and therefore affect organ microcirculation.In orderto examine the blood flowin the prostate, we used the data from laser Doppler flowmetry obtained using the laser analyzer LAKK-02. This diagnostic technique, aimed at detecting various microcirculatory defects, is more accurate, sensitive and enables longer time of exposure.

Results. After the course of treatment, we revealed the improvement of arterial blood flow in the prostate, elevation of blood perfusion and arteriolar flow and the boost of prostate microcirculation. We also noticed the decrease of hypoxia and ischaemization of prostate tissues and the presence of active mechanism of blood flow regulation in the prostate.

Conclusion. Hypercapnic hypoxia largely contributes to prostate microcirculation, which indicates its effectiveness for treating CAP

Authors declare lack of the possible conflicts of interests