Introduction. D-Mannose is an endogenous monosaccharide necessary for N-glycosylation of almost one third of the human proteome, including IgA, IgG, IgM, IgD, IgE and other immunoreceptors.

Materials and methods. A computational analysis of 33064 publications on D-mannose found in PUBMED (query "D-mannose OR mannose") was performed using modern methods of big data analysis developed in the framework of topological and metric approaches to recognition / classification problems. The article presents an analysis of 49 representative scientific articles that are relevant to the subject of this study.

Results. A systematic analysis of 33064 studies indicated the importance of D-mannose for glycosylation of human proteome proteins, support of functions not only of the urinary, but also of the cardiovascular, nervous, and immune systems, including maintaining antibacterial and antiviral immunity. The most studied clinical use of D-mannose is the treatment of bacterial cystitis. Promising directions for the use of D-mannose are the reduction of chronic inflammation and the prevention of tumor pathology, especially in menopausal women.

Conclusion. D-mannose is an effective and safe treatment for bacterial cystitis and, also, helps to reduce chronic inflammation.

Conflict of interest. The authors declare no conflict of interest