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Number №1, 2022 - page 178-184

The first results of the use of stem cells in the treatment of stress urinary incontinence in women DOI: 10.29188/2222-8543-2022-15-1-178-184

For citation: Nechiporenko A.N., Pinchuk S.V., Vasilevich D.M., Vasilevich I.B., Nechiporenko N.A., Volotovsky I.D. The first results of the use of stem cells in the treatment of stress urinary incontinence in women. Experimental and Clinical Urology, 2022;15(1):178-184; https://doi.org/10.29188/2222-8543-2022-15-1-178-184
Nechiporenko A.N., Pinchuk S.V., Vasilevich D.M., Vasilevich I.B., Nechiporenko N.A., Volotovsky I.D.
Information about authors:
  • Nechiporenko A.N. – Dr. Sc., Professor of the Department of Surgical Diseases II, Educational Institution «Grodno State Medical University»; Grodno, Republic of Belarus; https://orcid.org/0000-0002-3304-6393
  • Pinchuk S.V. – PhD, Senior Researcher, Laboratory of Cell Molecular Biology, the State Scientific Institution «Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus»; Grodno, Republic of Belarus; https://orcid.org/0000-0002-5499-5950
  • Vasilevich D.M. – urologist-specialist of the urological department of Healthcare facility «Grodno University Hospital»; Grodno, Republic of Belarus; https://orcid.org/0000-0002-0052-5195
  • Vasilevich I.B. – Researcher, Laboratory of Cell Molecular Biology, the State Scientific Institution «Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus»; Grodno, Republic of Belarus; https://orcid.org/0000-0002-3384-8038
  • Nechiporenko N.A.– Dr. Sc., Professor, Department of Surgical Diseases II, Educational Institution «Grodno State Medical University»; Grodno, Republic of Belarus; https://orcid.org/0000-0002-1544-9287
  • Volotovsky I.D. – Dr. Sc., Professor, Academician, Leading researcher, Laboratory of Cell Molecular Biology, the State Scientific Institution «Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus»; Grodno, Republic of Belarus; https://orcid.org/0000-0002-0242-0805
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Introduction. Stress urinary incontinence is a problem not only for the female, but is also a social, medical and economic issue for the community. The main method of treating stress urinary incontinence in women is surgical intervention with the use of synthetic mesh tape. Possibilities of intra and post-surgical complications is a major setback of surgical treatment. Attempts to restore/improve urethral sphincter functions by implanting stem cells has become a perspective method.

Methods and materials. Ten female patients from the Urological Clinic of the Grodno State Medical University were chosen for treatment using autologous mesenchymal stem cells. All of them were undergone tourological and gynecological examinations. All chosen patients filled in an Incontinence Quality of Life questionnaire, related to the continention of urine before and after the implant of stem cells. After the explantation of fatty tissue, autologous mesenchymal stem cells were extracted and cultivated, a mixture of stem cells with a gelatine-based substance. Stem cells were introduced para-urethrally and into the urethral wall.

Results. After 12 months after the implant 9 women completely retained urine during physical activity. No imperative disorders noted. One patient continued losing urine during physical activity, and her condition remained without improvement.

Conclusion. A positive result by criteria of urine retention, urination disorder, and a subjective evaluation of quality of life was achieved in 90% of patients. A lack of even a small positive effect on one patient gives evidence to pathological changes in the organs of the genitourinary, in which stem cell therapy has a low effectiveness. First results inspire a careful optimism, but a continuation of research is required due to a small number of observations.

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stress urinary incontinence; autologous mesenchymal stem cell implant

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