Introduction. Shock wave therapy (SWT) has been used quite successfully to treat erectile dysfunction (ED). However, the question of the optimal SWT regimen for the treatment of erectile dysfunction remains unresolved and is the subject of discussion among both physicians and manufacturers of medical equipment.

Purpose of the study. Develop and substantiate the most effective SWT regimen for the treatment of erectile dysfunction, based on the analysis of 28 scientific clinical studies.

Metrials and methods. To solve the problem, we analyzed 28 scientific clinical studies containing data on the use of shock wave therapy in the treatment of vasculogenic ED in a clinical setting.

Results. In the field of research, we developed and substantiated the SWT scheme for the treatment of vasculogenic ED. The scheme consists of a 9-week course (3 – therapy, 3 – break, 3 – therapy), contains 12 procedures (2 procedures per week); impulses are applied to 5 points, 500 impulses each (2500 per procedure); the total number of impulses per course is 30,000.

Conclusions. Thus, we have proposed a differential approach to the choice SWT regimen for the treatment of vasculogenic ED. Conservative tactics involves the use of medications (primarily PDE-5). Nevertheless, SWT can and should be applied within the framework of this tactic, and the optimal scheme is established mathematically by analyzing the literature data. Within the framework of a differentiated approach, we have determined the optimal schemes for conducting shock wave therapy in the treatment of vasculogenic erectile dysfunction.