Introduction. Modern medicine is developing every year and increasingly touches upon the aspect of male infertility, which can be a harbinger of the patient's future health. Understanding the mechanisms that fertility is a window to health opens new opportunities for important studies devoted to interdependent physiological processes. Identifying healthy individuals at risk for future cardiovascular disease, diabetes or cancer may allow changing reproductive medical care by changing long-term surveillance and reducing risk. Of course, the close relationship between infertility and health can be due to genetic, developmental and lifestyle factors. One of the main limiting factors in this regard is a poor understanding of the molecular features that link infertility with comorbidities throughout life. Enzymes involved in the process of lipid oxidation may provide new clues to reconcile the mechanistic basis of infertility with comorbidities.

Materials and methods. Based on the analysis of 58 publications presented in the Pub Med database on this issue, the possible association of male infertility with oncological, cardiovascular, metabolic and autoimmune diseases was studied.

Results. It is important to note that this analysis revealed not only the association of male infertility with an increased risk of developing oncological, cardiovascular, metabolic and autoimmune diseases, but also as a possible predictor of hospitalization and mortality in men.

Conclusion. Additional research is needed to clarify the specific mechanisms by which male infertility has a direct impact on the patient's somatic health.