Introduction. Aging is a complex biological phenomenon that encompasses all organs and systems of the human body, including the urinary system. The theory of inflammatory aging suggests that the senescence process is accompanied by the formation of chronic inflammation, activation of oxidative stress and the production of inflammatory or profibrotic cytokines, which ultimately leads to fibrotic tissue transformation and the development of functional organ deficiency and, in particular, plays a key role in age-associated bladder restructuring. With this in mind, it seems promising to study the possibilities of medicinal effects on the above-mentioned factors of preparations with proven anti-inflammatory and antioxidant activity.

Aims. To study the effectiveness of pharmacological correction of pathogenic factors (free radical oxidation, endothelial dysfunction and low-level ageassociated inflammation) in the paradigm of the theory of inflammatory fibrosis-mediated aging of the bladder using alpha lipoic acid in the form of monotherapy and in combination with coenzyme Q10.

Materials and methods. 30 mongrel sexually mature healthy white rats were used in the experiment. The animals were divided into three groups: control group (elderly animals without therapy, n=10); group 1 (elderly animals receiving alpha-lipoic acid monotherapy, n=10); group 2 (elderly animals receiving combined alpha-lipoic acid therapy in combination with coenzyme Q10, n=10). Markers of low-level age-associated inflammation (TNF-α, IL-6, IL1RA), endothelial dysfunction (ET-1, IL-1β, ESM1), profibrotic status (TGF beta 1 and CTGF), free radical oxidation (8-isoprostane, malondialdehyde, diene conjugates, catalase). The Students criterion was used to compare two groups with a normal distribution.

Results and discussion. Alpha-lipoic acid therapy led to a decrease in both plasma and tissue indicators of low-level inflammation, endothelial dysfunction, and lipid peroxidation. At the same time, combined treatment with alpha-lipoic acid in combination with coenzyme Q10 gave better results compared to monotherapy, leading to an improvement not only in the above indicators, but also in the levels of profibrotic molecules, as well as its own antioxidant activity (an increase in the level of endogenous catalase).

Conclusion. The dual combination of Alpha-lipoic acid and coenzyme Q10 has an advantage over monotherapy, causing an increase in antioxidant activity and reducing levels of proinflammatory and profibrotic cytokines in residential rats.