Introduction. It is estimated that Peyronie's disease (PD) affects approximately 3–9% of men worldwide and may be associated with pain, erectile dysfunction, and penile deformity, including shortening of the penis. This condition has a significant negative impact on the quality of life, self-esteem and psychological well-being of men. Purpose. Еvaluate the data published on May 2020 on the most effective and safe methods of medical and other non-surgical treatment of Peyronie's disease.

Materials and methods. the search results in scientific databases PubMed, MEDLINE, Embase were analyzed for the queries «Peyronie's disease», «medical treatment», «non-surgical treatment», «intralesional injections». Totally 74 papers were included in recent review after exclusion of duplicates, conference proceedings and literature review.

Results: Non-surgical treatment, including oral, traction, shock wave and intralesional injection therapy, can allow patients to avoid complications associated with surgery, and achieve improved functional and aesthetic results. Currently, several non-surgical treatment options are used in the treatment of PD, which can reduce or stabilize both objective indicators (for example, penis length and deformation) and subjective indicators (including sexual function, pain and partner satisfaction).

Conclusions. Оral therapy may include para-aminobenzoic acid, D-a-tocopherol and L-carnitine; verapamil, clostridial collagenase may be recommended as injection therapy. Extracorporeal shock wave therapy can be used in the Russian Federation as part of clinical trials.