Introduction. Postcoital cystitis is a form of lower urinary tract infection and accounts for up to 60% of all episodes of recurrent cystitis in women. Pre- or postcoital prophylaxis is used to prevent its development. Non-antibiotic topical agents have significant potential in this regard. These include the lubricant gel Cystalis®,which contains components that inhibit the development of cystitis – D-mannose, hyaluronic acid, and lactic acid.
Study objective. To study the anti-adhesive and antibacterial activity of Cystalis® gel against uropathogens that cause postcoital cystitis.
Material and methods. The microbiological study involved 50 strains of uropathogenic microorganisms isolated from the urine and vagina of women with postcoital cystitis. The presence and duration of direct antibacterial action and the strength of the anti-adhesive effect of Cystalis® gel in vitro were assessed.
Results. An anti-adhesive effect of the test product was observed. The adhesion index values for Cystalis® gel were significantly lower than those of the control. For E. coli, this difference was 2.5 times, for K. pneumoniae – 4.7 times, and for E. faecalis – 5.1 times. The obtained data also indicate direct antibacterial activity of the test product against uropathogens. Diluting the gel to a 1:4 ratio of the initial concentration inhibited the growth of E. coli, K. pneumoniae, and E. faecalis. The antibacterial activity of Cystalis® gel developed after 3 hours and was consistently maintained throughout the 24-hour study period.
Conclusion. The results of the study demonstrate the high microbiological efficacy of Cystalis® gel against the main uropathogenic microorganisms. Studying the use of Cystalis® gel for the prevention of postcoital cystitis in clinical settings appears promising.
