Introduction. Postcoital cystitis, which has a chronic form, can be attributed to a type of chronic cystitis in women. In the absence of positive dynamics from behavioral therapy, herbal and antimicrobial drugs used before or after sexual intercourse to prevent exacerbation of postcoital cystitis, the priority is the use of complexes of substances that strengthen the immune system, improve the condition of the bladder mucosa and have an antimicrobial effect.

Objective: to evaluate the efficacy and safety of the drug Nephronerei for the prevention of postcoital cystitis in women.

Materials and methods. The study included 80 women with chronic postcoital cystitis, who were divided into two groups of 40 people depending on the treatment received: group – patients took Nephronerey once, 1 sachet after each sexual intercourse, and group 2 – patients took only herbal uroseptics. The observation period was 180 days.

Results. It was found that the use of Nephronerey (1 sachet after each sexual contact) for six months significantly reduces the likelihood of relapses, reducing them threefold. Good tolerability of the drug, a noticeable decrease in the frequency of exacerbations and, as a result, a significant improvement in the quality of life of patients were noted.

Conclusions. The drug Nephronerey can be recommended for the prevention of postcoital cystitis.