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The role of infection of male accessory glands and leukospermia in andrological practice DOI: 10.29188/2222-8543-2025-18-2-84-89
- Ibragimov Sh.Sh. – Urologist, City Outpatient clinic No. 64, Moscow Healthcare Department; Moscow, Russia; https://orcid.org/0009-0007-7702-136X
- Zhivulko A.R. – PhD, Urologist, Center for Immunology and Reproduction LLC; Moscow, Russia; RSCI Author ID 1252314; https://orcid.org/0000-0002-1651-4343
- Monakov D.M. – PhD, Senior Researcher, Department of Oncourology, A.V. Vishnevsky National Medical Research Center of Surgery; Associate Professor, Department of Urology and Operative Nephrology with a Course of Oncourology, RUDN University of Russia; Moscow, Russia; RSCI Author ID 995385; http://orcid.org/0000-0002-9676-1802
- Gritskevich A.A. – Dr. Sci., Head of the Department of Oncourology and Urology of the A.V. Vishnevsky National Research Medical Center of Surgery of the Ministry of Health of the Russian Federation; Professor of the Department of Urology and Operative Nephrology with a course in Oncourology at the RUDN University of Russia; Moscow, Russia; RSCI Author ID 816947; https://orcid.org/0000-0002-5160-925X
- Olefir Y.V. – Dr. Sci., Professor, I.M. Sechenov First Moscow State Medical University; Moscow, Russia; RSCI Author ID 816947; https://orcid.org/0000-0001-7652-4642
- Kostin A.A. – Dr. Sci., corresponding member of the Russian Academy of Sciences, professor, first vice-rector-vice-rector for scientific work of the RUDN university, head of the urology department with courses of oncourology, radiology and andrology of the faculty of Continuous Medical Education, RUDN University of Russia; RSCI Author ID 193454;http://orcid.org/0000-0002-0792-6012
363 Introduction. The inflammatory process in the accessory male sex glands is considered as one of the factors of reducing male fertility, however, the pathogenetic mechanisms of the development of generative dysfunction in this pathology remain poorly understood.
Materials and methods. The search, analysis and synthesis of relevant publications in PubMed databases was carried out, eLibrary.ru, cyberleninka.ru by keywords. As a result, 38 publications were selected, which are included in this review.
Rusults. Leukospermia is detected in 10-20% of infertile men. An increase in the concentration of leukocytes in the ejaculate in response to the introduction of a bacterial infection is a marker of the inflammatory process developing in the accessory sex glands. An increase in the production of free radicals by activated leukocytes contributes to the development of oxidative stress, one of the main mechanisms of the development of male infertility. Their pathogenetic significance requires further study. It is not clear whether leukospermia and infections of the accessory sex glands have an impact on the results of assisted reproductive technologies (ART).
Conclusion. Inflammation of the accessory sex glands can affect male fertility by increasing the concentration of free radicals in the ejaculate. These pathogenetic mechanisms require further study in relation to clinical practice.
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