Frequency and nature of symptoms of dysfunction of the lower urinary tract in persons over 40 years old
Postcoital cystitis as a cause of sexual dysfunction in women
A modern view on the screening of urolithiasis
Hereditary factor of metaphylaxis of urolithiasis
Treatment of infertility associated with a high level of sperm DNA fragmentation
COVID-19 associated encrusting cystitis
Endoscopic correction of vesicoureteral reflux in children: differentiated choice of method, material and dosage
Male infertility in the Russian Federation: statistics for 2000-2018
Evaluation of the effectiveness of perineum muscle training in restoring erectile function
Epidemiology of urolithiasis in the Perm region: results of a 30-year study
The economic and economic rationale for the use of modern methods of treating urolithiasis
Incidence of ICD in the Russian Federation (2005-2016)
Screening for prostate cancer: modern presentation and organization
Primary multiple transitional cell epithelium
Androgenic screening in men over 50 years
The role of stem cells in the treatment of urinary incontinence
Percutaneous nephrolithotripsy in infected urine
Testicular Prosthesis in Children and Adolescents: Results from a Multicenter Study
Premature ejaculation is the current state of the problem.
Alternative methods of treatment of localized prostate cancer
Partial doubling of the urethra: paraurethral motion
Comparative review of disposable flexible ureteronephroscope
The prevalence of symptoms of impairment of the function of the lower urinary tract in men according to the results of a population study
Patient-centered system of organization of medical care in urology using...
Radioisotope lymphoscintigraphy with PCa
Metabolic risk factors and formation of urinary stones
Ureteral amputation in the performance of contact ureterolithotrypsy
Principles of «4P Medicine» in the organization of health care in the context of urological diseases
Changes in the electrolyte composition of urine under the influence of sodium hypochlorite. The possibility
of reducing the risk of recurrence of nephrolithiasis
The analysis of the accuracy of factors for the survival predictiry after radical cystectomy
Citokine status in pathients with recurrent urinary tract infection
The role of distance education in improving primary health care professionals.
Comparative analysis of the results of cancer radical retropubic and robot-assisted prostatectomy.
Experience of clinical and economical treatment cancer patients
Comparison of analysis details for open, laparoscopic
and robot-assisted nephrectomy in the..
First results of standardized programme for BPH diagnosis and treatment
Evaluation of serum Chromogranin A levels in different prostatic diseases
Retarded ejaculation is a rare diagnosis
Clinical and economic analysis of the surgical treatment of prostate cancer
Brachytherapy prostate cancer: postimplantnaya dosimetry and dependence ...
Simulation prostatic carcinogenesis
Okhobotov D.A. − Ph.D., Urologist, Medical Research and Education Center, Lomonosov Moscow State University, Senior Lecturer, Department of Andrology and Urology, Faculty of Fundamental Medicine; Moscow, Russia; https://orcid.org/0000-0002-6768-9004
Sagaradze G.D. – PhD, junior researcher, Medical Research and Education Center, Lomonosov Moscow State University; Moscow, Russia; https://orcid.org/0000-0003-2551-5118
Monakova A.O. – student of the Faculty of Fundamental Medicine Lomonosov Moscow State University; Moscow, Russia
Basalova N.A. – PhD student, Faculty of Fundamental Medicine Lomonosov Moscow State University; Moscow, Russia; https://orcid.org/0000-0002-2597-8879
Balabanyan V.Yu. – PhD, leading researcher at the Interfaculty Research Laboratory of Translational Medicine, leading researcher at Lomonosov Moscow State University; Moscow, Russia
Popov V.S. – PhD, head of the Interfaculty Research Laboratory of Translational Medicine, leading researcher at Lomonosov Moscow State University; Moscow, Russia; https://orcid.org/0000-0002-5039-7152
Kirpatovskiy V.I. – Dr. Sc., Professor, leading researcher at Lomonosov Moscow State University; Moscow, Russia; https://orcid.org/0000-0002-4356-9200
Nesterova O.Yu. – resident physician at the Department of Urology and Andrology of the Faculty of Fundamental Medicine Lomonosov Moscow State University; Moscow, Russia; https://orcid.org/0000-0003-3355-4547
Efimenko A.Yu. – Ph.D., head of laboratory of tissue repair and regeneration, Institute for Regenerative Medicine, Medical Research and Educational Centre, Lomonosov Moscow State University; Moscow, Russia; https://orcid.org/0000-0002-0696-1369
Kamalov A.A. – Professor, Dr. Sc., Academician RAS, Director, Medical Research and Education Center of Lomonosov Moscow State University Head of the Department of Urology and Andrology Faculty of Fundamental Medicine, Lomonosov Moscow State University; Moscow, Russia; https://orcid.org/0000-0003-4251-7545
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Introduction. Cisplatin and Doxorubicin have pronounced toxic effects on spermatogenesis. Modeling of spermatogenesis disorders using these drugs can become convenient and relevant when conducting preclinical studies to assess the specific activity of new drugs for the treatment of toxic cases of male infertility.
Objective. Тo evaluate the possibility of using Cisplatin and Doxorubicin for spermatogenesis disorders in vivo experiments.
Materials and methods. In our study a model of spermatogenesis disorders caused by Cisplatin and doxorubicin was tested in mature male Wistar rats and mice of the C57BL/6 breed group. Cisplatin was administered intraperitoneally once at doses of 1 mg/kg, 2 mg/kg, 3 mg/kg and 4 mg/kg (2 rats in each group). The severity of spermatogenesis disorders was evaluated on the 14th and 28th days after administration. With multiple regimens, cisplatin was administered at a dose of 4 mg/kg for 3-5 days (8 rats per group). Doxorubicin was administered intraperitoneally at doses of 1,5 mg/kg and 3 mg/kg (5 mice in each group). The severity of spermatogenesis disorders was evaluated on the 35th day. The comparison of drug use modes was carried out using the Mann-Whitney U-test.
Results. A single administration of Cisplatin did not lead to a violation of spermatogenesis. Multiple administration of Cisplatin caused severe general toxicity and animal lethality, and the maximum percentage of damaged tubules was only 9.1%. Doxorubicin in all used doses caused severe structural disorders, edema and spermatogenesis disorders in almost 100% of tubules.
Conclusion. Using of Doxorubicin is reasonable for gonadotoxic effect modeling due to the long-term spermatoxic effects along with lower animal lethality. Thus, Doxorubicin model can be useful for evaluation of specific pharmacological activity of potential drugs – regeneration stimulants for the treatment of male infertility
5-year impact factor of Russian science citation index from 15.01.2020 - 0,723
10-year H-index 21
Included in the Russian Science Citation Index (RSCI)
ISSN print 2222-8543 ISSN online 2712-8571
The journal is included in the List of Russian peer-reviewed scientific journals which should publish the main scientific results of dissertations for the degrees of Doctor and PhD of sciences
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