Дрожжева В.В.

Introduction. Acidity of urine is an important factor that can have a modulating effect on the formation of kidney stones. The formation of certain types of urinary stones (oxalate, phosphate, urate, cystine) is largely dependent on the urinary pH. However, the acidity of urine is not the only factor determining the ability urine to stone formation. The lithogenic potential of urine is the result of the interaction of various factors, both metabolic and physicochemical ones, including urine pH.

Introduction. Chronic ischemia is an important pathogenic factor of urination disorders in patients with benign prostatic hyperplasia (BPH). The aim of this study was to investigate the rationale for administering the drugs with anti-ischemic action in order to improve the urinary bladder function after acute urinary retention (AUR).

Objective. Experimental study of the effect of sodium hypochlorite (SH) on renal function and hormonal status intact rats, influencing the composition of the final urine.

Elevated excretion of inorganic phosphates (more than 33.6 mmol/ day) and magnesium (more than 5.1 mmol/ day) increased the risk of oxalate stone formation in patients with urolithiasis (200 males and 237 females, aged from 16 to 75). Phosphaturia and magnesiumuria were accompanied by the rise in the level of calcium and uric acid excretion and the increase in urine acidity, which, presumably, are the additional factors, which promote oxalate lithogenesis.

We have examined mineral composition of 437 urinary con-crements obtained from 200 men and 237 women. The levels of daily urinary excretion of calcium and uric acid were also analyzed. We have shown that the increase of calcium excretion (more than 6.6 mmol per day) increases the incidence of oxalate stone formation. In this case, the relative risk index was 1.76, in comparison with patients, whose level of calcium excretion was less than 2.6 mmol per day (-p=0. 0018)

The aim of the research. Experimental study of the sodium hypochlorite (SH) effect on the blood and urine electrolyte composition, cations and anions, that are part of the urinary stones, which are recognized risk factors for urolithiasis.

Introduction. Benign prostatic hyperplasia and associated diseases develop significantly more often in patients with metabolic syndrome (MS) in comparison with a general male population of the same age. The pathogenesis of these conditions requires a special research.

The mineral composition of the 437 urinary stones was studied in 437 patients with urolithiasis aged from 16 to 75 years, which have been treated in the National Scientific Urological Institute. Body-mass index (BMI), blood biochemistry panel and biochemistry of 24-hour urine probe were evaluated in all patients. Quartile analysis of the data was done according to the BMI distribution. Lower quartile was represented by BMI values < 24.1 kg/m2 (n=99), upper quartile by BMI values > 33.1 kg/m2 (n=99).

In this experimental work on 28 female inbreed rats we have studied the action of the complex of anti-ischemic medications (alpha-tocopherol, trental, mexidol and diltiazem in a daily dosage 10 mg/kg, 4 mg/kg, 5 mg/kg and 2 mg/kg, correspondingly) and alpha-adrenoblocker doxazosin in a daily dosage 0.05 mg/kg with the background of the modelled infravesical obstruction via the dosed compression of the infravesical urethra.

We have investigated the crystalforming activity of the urine in 111 patients (age 23-67 years) with oxalate urolithiasis, among them – 68 patients with non-recurrent form (39 male and 29 female patients) and 43 patients with recurrent form (27 men and 16 women). Eighty-six healthy patients without urological diseases were used as control (38 male and 48 female patients) with the age 21-62 years.