Соловьев А.С.

Introduction. This article is dedicated to the clinico-pathogenetic aspects of antioxidant therapy in the correction of age-related bladder dysfunction. Current data indicate a correlation between aging and chronic inflammation and oxidative stress, described by the theory of «inflam-maging». Despite the proven effectiveness of antioxidants in experimental models, their clinical significance in geriatric and urological practice requires further study.

Introduction. Despite the absence of a generally accepted theory explaining the mechanisms of aging, existing scientific data indicate a close relationship between aging and chronic low-grade inflammation (low-grade inflammation). This theory of inflammatory aging (inflame-aging) suggests that aging is accompanied by the development of a chronic inflammatory phenotype, which ultimately leads to fibroplastic transformation of tissues, which manifests itself in a functional deficiency of organs and, in particular, the bladder.

Materials and methods: 120 patients with chronic bacterial prostatitis under clinical and laboratory exacerbation (study group) and 30 clinically healthy men (control group) were examined. The mean age in the study group was 39.6 ± 0.96 years, in the control group 36.8 ± 0.95 years. In all patients, the endothelial function markers were determined: metabolites of NO, endothelin I, free L-arginine, homocysteine, a test with reactive hyperemia was performed.

Summary. Purpose of the study. To study the nature and frequency of the manifestations of endothelial dysfunction and to clarify their relationship with pain syndrome in patients with exacerbation of chronic bacterial prostatitis (CBP).