Introduction. Recurrent infection of the lower urinary tract (UTI) is a very common pathology in women of different age groups. This category of urological patients is most often found in the practice of an outpatient urologist.

Aim. To study the possibilities of the effect of hydrolytic enzymes on the effectiveness of complex antiinflammatory therapy of chronic infectious and inflammatory diseases of the lower urinary tract in women with pathology of the distal urethra, paraurethral region and on the results of surgical treatment of patients with female hypospadias, paraurethral cysts.

Materials and methods. 96 patients with various forms of chronic lower UTI and its complications as a result of diseases of the urethra and paraurethral zone (female hypospadias, hypermobility of the urethra, paraurethral cyst) we was observed. In the course of our study, all the observed patients, were divided into 2 groups. Group I – 40 people (control) patients who received only anti-inflammatory and antibacterial therapy according to the spectrum of the detected pathogen of UTI in combination with surgical treatment, and the group II – 56 patients who received anti-inflammatory and antibacterial therapy according to the spectrum of the detected pathogen of UTI and surgical treatment in combination with enzyme therapy for a course of 14 days.

Results. In the II group all patients after discharge from the hospital were monitored for 6 months. Only 1 patient had a relapse of exacerbation of chronic lower urinary tract infection. Enzyme therapy as a component that optimizes anti-inflammatory therapy provides a real chance for earlier relief of the infectious process in these patients and improvement of the results of surgical treatment of paraurethral pathology.

Discussion. Chronic recurrent infection of the lower urinary tract in women is often associated with the presence of pathological conditions of the distal urethra in the form of female hypospadias and hypermobility of the urethra, as well as paraurethral pathology in the form of paraurethral cysts. Patients with this pathology need surgical treatment and mandatory complex anti-inflammatory therapy. Enzyme therapy as a component that optimizes anti-inflammatory therapy provides a real chance for earlier relief of the infectious process in these patients and improvement of the results of surgical treatment of paraurethral pathology.

Conclusion. The inclusion of hydrolytic enzymes in patients with UTI and with diseases of the distal urethra and paraurethral region in the anti-inflammatory therapy regimen increases the effectiveness of etiotropic therapy and improves the results of surgical treatment of diseases of the distal urethra and paraurethral region.

Conflict of interest. The authors declare no conflict of interest.