Introduction. One of the most common multifactorial disease states, which is caused by certain systemic diseases, as well as the reception of drugs and psycho-emotional status of the person is insomnia.

Materials and methods. Palpitations nighttime urination is the most common reason for seeking medical care for patients suffering from lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH). Nocturia and insomnia are interrelated pathological states, each of which contributes significantly to the decline in the quality of life of patients, which manifests itself daily dysfunction and impaired social and occupational functioning. Currently, there are two points of view on the cause nocturia and insomnia. The first a "urological theory" that shows that the cause of insomnia showing frequent nighttime urination. ?e second belongs to the professionals involved in the problems of sleep disturbance claim that nocturia is due to insomnia.

Results and discussion. ?e results of the combined alpha-adrenolitic and antiinsomniac therapy of patients with lower urinary tract symptoms / benign prostatic hyperplasia on the background of refractory nocturia.

Conclusion. It is proved that supplementation hypnotic drug (zaleplon) in the treatment of LUTS/ BPH is an effective and safe way to correct refractory nocturia in patients with concomitant insomnia.

Authors declare lack of the possible conflicts of interests.