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Brumberg V.A. – researcher at laboratory № 1 of the center for biomedical technologies of the A.I. Burnazyan state research center of the Federal STATE medical University of Russia; Moscow, Russia
Astrelina T.A. – Dr. Sc., associate Professor, head of the center for biomedical technologies of the A.I. Burnazyan state medical CENTER of the Russian Federation; Moscow, Russia; https://orcid.org/0000-0003-3629-0372
Kazhera A.A. – doctor of the Center of urology and andrology SSC FMBC of A.I. Burnazyan of FMBA of Russia; Moscow, Russia; https://orcid.org/0000-0002-4108-4066
Kyzlasov P.S.– Professor of Department of urology and andrology SSC FMBC of A.I. Burnazyan of FMBA of Russia, Dr.Sci. Med; Moscow, Russia; https://orcid.org/0000-0003-1050-6198
Troyakov V.M. – post-graduate student of the Department of urology and andrology SSC FMBC of A.I. Burnazyan of FMBA of Russia; Moscow, Russia
Kobzeva I.V. – PhD, head of Cryobank of the Center for biomedical technology, doctor of medical SSC, FMBC SSC center named after them. A. I. Burnazyan of FMBA of Russia; Moscow, Russia
Nikitina V.A. – PhD, senior researcher of laboratory №9 center of biomedical technology, SSC FMBC of A.I. Burnazyan of FMBA of Russia, a member of ISCT; Moscow, Russia; https://orcid.org/0000-0002-3150-7686
Karaseva T.V. – Head of the Department of biomedical technologies expertise and coordination of clinical research аt the center for biomedical technologies, FMBC of A.I. Burnazyan of FMBA of Russia; Moscow, Russia
Malivanova T.F. – PhD, senior researcher at the genome editing laboratory оf the center for biomedical technologies of the SSC FMBC of A.I. Burnazyan of FMBA of Russia; Moscow, Russia; https://orcid.org/0000-0001-9699-2603
Usupzhanova D.Yu. – Junior research associate of laboratory No.1 of the center for biomedical technologies of the SSC FMBC of A.I. Burnazyan of FMBA of Russia; Moscow, Russia
Brunchkov V.A. – Junior researcher of the laboratory for genome editing of the biomedical technologies SSC FMBC of A.I. Burnazyan of FMBA of Russia; Moscow, Russia
Rastorgueva A.A. – Junior researcher of the laboratory for genome editing of the biomedical technologies SSC FMBC of A.I. Burnazyan of FMBA of Russia; Moscow, Russia
Lishchuk S.V. – pathologist, head of pathology Department, research SSC center named of A.I. Burnazyan of FMBA of Russia, PhD Med; Moscow, Russia; https://orcid.org/0000-0003-0372-5886
Dubova E.A. – Dr. Sc., doctor – pathologist of pathology Department of SSC FMBC of A.I. Burnazyan of FMBA of Russia; Moscow, Russia; https://orcid.org/0000-0002-7115-538X
Smolev D.M. – PhD, radiologist Department of radiation and radioisotope diagnostic of SSC FMBC of A.I. Burnazyan of FMBA of Russia; Moscow, Russia; https://orcid.org/0000-0002-9180-487
Bashkov A.N. – PhD, radiologist, head of Department of radiation and radioisotope diagnostic of SSC FMBC of A.I. Burnazyan of FMBA of Russia; Moscow, Russia; https://orcid.org/0000-0002-4560-6415
Samoilov A.S. – Dr. Sc., Prof. of RAS, the General Director of SSC FMBC of A.I. Burnazyan of FMBA of Russia; Moscow, Russia
704
Introduction. Urethral stricture is a complex and urgent problem in operative urology. The main problem in the treatment of extended structures of the posterior urethra is the inability to form an adequate urethral site for augmentation urethroplasty with the common buccal graft, which has a priority in the treatment of penile strictures. The use of tissue acellular matrices may be promising in the development of reconstructive urology, which in the future will solve a number of problems associated with augmentation urethroplasty.
The purpose of this article is to study the possibility of using a cell-free matrix of a donor artery as a free flat flap for stricture replacement urethroplasty on a model of laboratory animals (rabbits).
Materials and methods. Donor blood vessels were Used, which were subjected to detergent-enzymatic perfusion decellularization. To assess the quality of the cell-free matrix, a histological study and an immunohistochemical study were performed. The cell-free flap of the donor artery was fixed to the protein envelope from the side of the simulated defect and posterior on-lay urethroplasty was performed.
Results and discussion. The resulting matrix was characterized by the absence of detectable cell nuclei, preserved type I collagen, and a DNA content of no more than 50 ng / mg of tissue. In the postoperative period, normal motor activity of animals, normal urination, weight loss was not observed. The levels of Creactive protein, creatinine, and urea in peripheral blood 5 months after surgery were within the normal range: 0.285±0.04839 mg / l, 93.5±8.057 mm / l, and 8.35±1.355 mm/l, respectively. If cystourethrography with the help of computer tomography data for stricture of the urethra is not revealed. During magnetic resonance imaging in the axial and sagittal projections, the patency of the urethra was indirectly confirmed.
Conclusion. In a laboratory animal model, it was shown that the resulting cell-free flap has in vivo biocompatibility and can be used for replacement urethroplasty of posterior urethral strictures.
5-year impact factor of Russian science citation index from 15.01.2020 - 0,723
10-year H-index 21
Included in the Russian Science Citation Index (RSCI)
ISSN print 2222-8543 ISSN online 2712-8571
The journal is included in the List of Russian peer-reviewed scientific journals which should publish the main scientific results of dissertations for the degrees of Doctor and PhD of sciences
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