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Number №1, 2022 - page 90-101

Chronic prostatitis/chronic pelvic pain syndrome: current trends and treatment prospects from the standpoint of evidence-based medicine DOI: 10.29188/2222-8543-2022-15-1-90-100

For citation: Tyuzikov I.A., Grekov E.A. Chronic prostatitis/chronic pelvic pain syndrome: current trends and prospects for treatment from the standpoint of evidence-based medicine. Experimental and Clinical Urology, 2022;15(1):90-100; https://doi.org/10.29188/2222‑8543‑2022‑15‑1‑90‑100
Tyuzikov I.A., Grekov E.A.
Information about authors:
  • Tyuzikov I.A. – PhD, urologist–andrologist, Professor of the Russian Academy of Natural History (RANH), MC «Tandem-Plus»; Yaroslavl, Russia; https://orcid.org/0000-0001-6316-9020
  • Grekov E.A. – urologist-andrologist, endocrinologist, Chief Physician of the Hormone Life Clinic; Moscow, Russia
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Introduction. Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in men remains an unresolved problem of urology due in sufficienty stadied etiopathogenesis, methodological problems of diagnosis and, as a consequence, unsatisfactory results of treatment, which includes pharmacotherapy and non-drug interventions of various levels of evidence of their effectiveness, which mainly to alleviate the symptoms of the disease. Monomodal therapy of CP/CPPS is currently recognized as ineffective, so today a multimodal phenotypic approach is recommended in order to increase the effectiveness of the methods used to treat the disease in a particular patient. To solve this problem, highly evidence-based data is needed at the moment, which would reflect the progress made so far in our ability to manage CP/CPPS.

Materials and methods. Search results were analyzed in scientific databases PubMed, Medline, Web of Science, Embase, Cochrane Library and PEDro, Wang-fang Database и Cnki, Edline on request «chronic prostatitis», «chronic pelvic pain syndrome», «drug treatment», «non-drug interventions», «efficacy», «safety».

Results. Non-drug, drug and promising methods of CP/CPPS were studied. The review illustrates and comprehensively discusses the available modern options for the treatment of CP/CPPS and outlines some promising new therapies. It has been shown that ongoing research and accumulating clinical data will further deepen our knowledge of CP/CPPS, clarify its etiology and pathophysiological mechanisms in order to develop and introduce new effective methods of treating CP/CPPS into wide clinical practice in the near future.

Conclusion. Despite the long scientific history of studying CP/CPPS, highly evidence-based meta-analyses and systematic reviews on many aspects of its drug and non-drug treatment have not yet been created, therefore, this literary review summarizes the results of the latest meta-analyses and systematic reviews of recent years evaluating the effectiveness of various modern methods of treatment of CP/CPPS from the standpoint of evidence-based medicine.

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chronic prostatitis (CP); chronic pelvic pain syndrome (CPPS); drug treatment; non-drug interventions; efficacy; safety; meta-analysis; systematic review

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