Introduction. Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in men remains an unresolved problem of urology due in sufficienty stadied etiopathogenesis, methodological problems of diagnosis and, as a consequence, unsatisfactory results of treatment, which includes pharmacotherapy and non-drug interventions of various levels of evidence of their effectiveness, which mainly to alleviate the symptoms of the disease. Monomodal therapy of CP/CPPS is currently recognized as ineffective, so today a multimodal phenotypic approach is recommended in order to increase the effectiveness of the methods used to treat the disease in a particular patient. To solve this problem, highly evidence-based data is needed at the moment, which would reflect the progress made so far in our ability to manage CP/CPPS.

Materials and methods. Search results were analyzed in scientific databases PubMed, Medline, Web of Science, Embase, Cochrane Library and PEDro, Wang-fang Database и Cnki, Edline on request «chronic prostatitis», «chronic pelvic pain syndrome», «drug treatment», «non-drug interventions», «efficacy», «safety».

Results. Non-drug, drug and promising methods of CP/CPPS were studied. The review illustrates and comprehensively discusses the available modern options for the treatment of CP/CPPS and outlines some promising new therapies. It has been shown that ongoing research and accumulating clinical data will further deepen our knowledge of CP/CPPS, clarify its etiology and pathophysiological mechanisms in order to develop and introduce new effective methods of treating CP/CPPS into wide clinical practice in the near future.

Conclusion. Despite the long scientific history of studying CP/CPPS, highly evidence-based meta-analyses and systematic reviews on many aspects of its drug and non-drug treatment have not yet been created, therefore, this literary review summarizes the results of the latest meta-analyses and systematic reviews of recent years evaluating the effectiveness of various modern methods of treatment of CP/CPPS from the standpoint of evidence-based medicine.