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Number №1, 2022 - page 155-161

Prevention of infectious and inflammatory complications during TUR of the prostate using Orcepol VM DOI: 10.29188/2222-8543-2022-15-1-155-160

For citation: Neymark A.I., Neymark B.A., Nozdrachev N.A., Melnik M.A., Kovaleva Yu.S. Prevention of infectious and inflammatory complications during TUR of the prostate using Orcepol VM. Experimental and Clinical Urology, 2022;15(1):155-160; https://doi.org/10.29188/2222-8543-2022-15-1-155-160
Neymark A.I., Neymark B.A., Nozdrachev N.A., Melnik M.A., Kovaleva Yu.S.
Information about authors:
  • Neymark A.I. – Dr. Sc., Professor, Head of the Department of Urology and Andrology with the course of additional postgraduate education of the «Altai State Medical University» of the Ministry of Health of the Russian Federation; Barnaul, Russia; https://orcid.org/0000‑0002‑5741‑6408
  • Neymark B.A. – Dr. Sc., Professor of the Department of Urology and Andrology with the course of additional postgraduate education of the «Altai State Medical University» of the Ministry of Health of the Russian Federation; Barnaul, Russia; https://orcid.org/0000‑0001‑8009‑3777
  • Nozdrachev N.A. – PhD, Associate Professor of the Department of Urology and Andrology with the course of additional postgraduate education of the «Altai State Medical University» of the Ministry of Health of the Russian Federation; Barnaul, Russia; https://orcid.org/0000-0003-3937-7270
  • Melnik M.A. – PhD, Assistant of the Department of Urology and Andrology with the course of additional postgraduate education of the «Altai State Medical University» of the Ministry of Health of the Russian Federation; Barnaul, Russia; https://orcid.org/0000‑0002‑2405‑0315
  • Kovaleva Yu.S. – Dr. Sc., Associate Professor, Head of the Department of Dermatovenereology, Cosmetology and Immunology of the «Altai State Medical University» of the Ministry of Health of the Russian Federation; Barnaul, Russia; ASMU; Barnaul, Russia; https://orcid.org/0000-0002-4401-3722
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Introduction. Transurethral resection (TUR) of the prostate (P) is the main method of surgical treatment of benign prostatic hyperplasia (BPH), while the risk of postoperative pyo-inflammatory complications in the postoperative period.

Material and methods. The study included 50 men with a diagnosis of BPH requiring surgical treatment. Patients were randomized into two groups, comparable in age, clinical manifestations and laboratory and instrumental parameters: group 1 (control) – 20 people and group 2 (main) – 30 people. Patients in both groups underwent TURP. In group 1, ciprofloxacin 200.0 mg IV during surgery was used as an antibacterial prophylaxis, and patients in group 2 received Orcepol VM 1 tablet 2 times a day for 5 days before surgery and 10 days after, the course of therapy was 15 days. Before the operation and 10 days after the operation, the urine was cultured for flora and sensitivity to antibiotics, and on the day of the operation, the resected tissue was also cultured. In all patients, renal microcirculation was assessed by laser Doppler flowmetry.

Results. After TURP, inflammatory changes in blood tests were more common in patients of group 1. The percentage of sterile cultures increased significantly in patients of group 2. Infectious and inflammatory complications in patients of group 1 were recorded significantly more often than in patients of group 2, against the background of prophylaxis with Orcepol. In the study of the state of microcirculation of the kidneys in patients of group 1 after surgery, significant changes in microcirculation were revealed compared with control values. These disorders persisted on the 10th day after the operation, which created favorable conditions for the development of ascending pyelonephritis. In patients of group 2, while taking the drug Orcepol VM, microcirculatory disorders in the postoperative period were insignificant and completely stopped on the 10th day.

Conclusions. Based on the data obtained, Orcepol VM can be recommended for the prevention of infectious and inflammatory complications of TURP as a monotherapy

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benign prostatic hyperplasia; BPH; transurethral resection of the prostate; TURP; infectious and inflammatory complications; Orcepol VM

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